Since 1991 the FIT has made a unique contribution to advancing the Science and Medicine of all types of Fungal diseases.
It has donated over £3,750,000 to research and education, primarily in the UK, with internal costs kept below 5%.

It supports the Aspergillus Website which is the world’s most comprehensive, dynamic and interactive portal for all aspects of Aspergillus and the diseases it causes. This is also a huge resource for patients and carers, with support groups, newsletters and blogs.

In 2009 the first centre of excellence for fungal disease was opened in Manchester under the NHS — The National Aspergillosis Centre.
The Aspergillus Website continues to underpin the National Aspergillosis Centre supporting patients, providing meetings and consultations, encouraging international involvement from Scientists and Doctors worldwide.
The ongoing support for this resource is essential for continuing education and research in a quest to provide the best treatments for patients who are unfortunate enough to be affected by Aspergillus.

The FIT has supported 25 researchers and medical practioners resulting in more than 180 research reports on fungi and fungal diseases. Funding has also been donated to  4 major scientific conferences in the UK and Europe.

Highlights of the last year include:

  • Establishing the use of St Georges Respiratory Questionnare (filled out by the patient) as an easy to use tool to predict clinical status and clinical changes over time for Chronic Pulmonary Aspergillosis.
  • Strengthening the case for beneficial effects of the use of antifungal drugs for the treatment of Chronic Pulmonary Aspergillosis.
  • Characterisation the importance of a new Aspergillus fumigatus species in invasive infection in dogs, cats and humans.
  • Reclassification of aspergillosis in Cystic Fibrosis patients into 3 distinct classes, aiding diagnosis and treatment.
  • Estimating for the first time the global burden of fungal diseases ABPA (4.8 million people) and CPA complicating ABPA (400, 000)
  • The detection of successive genetic changes in single fungal balls (aspergilloma) that reveal improvements in diagnostic techniques are needed.

Highlights of 2013 include:

  • Showing a link between chronic Candida infection of the oesophagus and cancer
  • Finding important genetic variations in a group of cell attachment proteins for fungi and bacteria, called Toll-like receptors’ that differ in patients with different Aspergillus diseases
  • Showing the extreme variation in blood levels of voriconazole (the powerful first-line treatment of life threatening aspergillosis) in children, requiring dosage adjustment
  • Major findings related to the remarkable differences and similarities in genomes and genes between different members of the Aspergillus genus
  • Improvements in standardisation of susceptibility for Candida and filamentous fungi, by supporting the work of the European Committee on Antifungal Susceptibility Testing
  • Contributing to remarkable new findings in chronic mucocutaneous candidiasis showing that these patients have auto-antibodies against type 1 interferons, and this may be a useful diagnostic test and diagnostic criterion.

2012 View Progress Report from 3rd year PhD scholar Laszlo Nagy. Laszlo Nagy Report 2011

Listing of papers generated with the support of FIT

2016

Al-Shair, K., Muldoon, E. G., Morris, J., Atherton, G. T., Kosmidis, C. and Denning, D. W. (2016) ‘Characterisation of fatigue and its substantial impact on health status in a large cohort of patients with chronic pulmonary aspergillosis (CPA).’ Respiratory medicine. 2016/04/26, 114. [Source]
Bartholomew, J. S., Banfield, S., Atherton, G. T. and Denning, D. W. (2016) ‘Comment on: Antifungal therapy: drug-drug interactions at your fingertips.’ The Journal of antimicrobial chemotherapy. 2016/03/06, 71(7). [Source]
Bromley, M., Johns, A., Davies, E., Fraczek, M., Mabey Gilsenan, J., Kurbatova, N., Keays, M., Kapushesky, M., Gut, M., Gut, I., Denning, D. W. and Bowyer, P. (2016) ‘Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi.’ PloS one. 2016/07/22, 11(7). [PubMed]
Denning, D. W., Cadranel, J., Beigelman-Aubry, C., Ader, F., Chakrabarti, A., Blot, S., Ullmann, A. J., Dimopoulos, G. and Lange, C. (2016) ‘Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management.’ The European respiratory journal. 2015/12/25, 47(1). [Source]
Gamaletsou, M. N., Drogari-Apiranthitou, M., Denning, D. W. and Sipsas, N. V. (2016) ‘An estimate of the burden of serious fungal diseases in Greece.’ European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2016/04/18, 35(7). [Source]
Gamaletsou, M. N., Rammaert, B., Bueno, M. A., Sipsas, N. V., Moriyama, B., Kontoyiannis, D. P., Roilides, E., Zeller, V., Taj-Aldeen, S. J., Henry, M., Petraitis, V., Denning, D. W., Lortholary, O. and Walsh, T. J. (2016) ‘Aspergillus arthritis: analysis of clinical manifestations, diagnosis, and treatment of 31 reported cases.’ Medical mycology. 2016/09/10. [Source]
Giacomazzi, J., Baethgen, L., Carneiro, L. C., Millington, M. A., Denning, D. W., Colombo, A. L. and Pasqualotto, A. C. (2016) ‘The burden of serious human fungal infections in Brazil.’ Mycoses. 2015/12/23, 59(3). [Source]
Gugnani, H. C. and Denning, D. W. (2016) ‘Burden of serious fungal infections in the Dominican Republic.’ Journal of infection and public health. 2015/06/02, 9(1). [Source]
Guto, J. A., Bii, C. C. and Denning, D. W. (2016) ‘Estimated burden of fungal infections in Kenya.’ Journal of infection in developing countries. 2016/09/01, 10(8). [Source]
Kneale, M., Bartholomew, J. S., Davies, E. and Denning, D. W. (2016) ‘Global access to antifungal therapy and its variable cost.’ The Journal of antimicrobial chemotherapy. 2016/08/16. [Source]
Langridge, P. J., Sheehan, R. L. and Denning, D. W. (2016) ‘Microbial yield from physiotherapy assisted sputum production in respiratory outpatients.’ BMC pulmonary medicine. 2016/02/03, 16. [PubMed]
Muldoon, E. G., Sharman, A., Page, I., Bishop, P. and Denning, D. W. (2016) ‘Aspergillus nodules; another presentation of Chronic Pulmonary Aspergillosis.’ BMC pulmonary medicine. 2016/08/20, 16(1). [PubMed]
Newton, P. J., Harris, C., Morris, J. and Denning, D. W. (2016) ‘Impact of liposomal amphotericin B therapy on chronic pulmonary aspergillosis.’ The Journal of infection. 2016/07/05. [Source]
Oladele, R. O., Akanmu, A. S., Nwosu, A. O., Ogunsola, F. T., Richardson, M. D. and Denning, D. W. (2016) ‘Cryptococcal Antigenemia in Nigerian Patients With Advanced Human Immunodeficiency Virus: Influence of Antiretroviral Therapy Adherence.’ Open forum infectious diseases. 2016/05/18, 3(2). [PubMed]
Page, I. D., Richardson, M. D. and Denning, D. W. (2016) ‘Comparison of six Aspergillus-specific IgG assays for the diagnosis of chronic pulmonary aspergillosis (CPA).’ The Journal of infection. 2015/12/19, 72(2). [Source]
Patterson, T. F., Thompson, G. R., Denning, D. W., Fishman, J. A., Hadley, S., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Nguyen, M. H., Segal, B. H., Steinbach, W. J., Stevens, D. A., Walsh, T. J., Wingard, J. R., Young, J. A. and Bennett, J. E. (2016a) ‘Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America.’ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2016/08/03, 63(4). [PubMed]
Patterson, T. F., Thompson, G. R., Denning, D. W., Fishman, J. A., Hadley, S., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Nguyen, M. H., Segal, B. H., Steinbach, W. J., Stevens, D. A., Walsh, T. J., Wingard, J. R., Young, J. A. and Bennett, J. E. (2016b) ‘Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America.’ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2016/07/02, 63(4). [PubMed]
Sintes, M., De Moliner, F., Caballero-Lima, D., Denning, D. W., Read, N. D., Kielland, N., Vendrell, M. and Lavilla, R. (2016) ‘Electrophilic, Activation-Free Fluorogenic Reagent for Labeling Bioactive Amines.’ Bioconjugate chemistry. 2016/06/02, 27(6). [Source]

2015

Badiane, A. S., Ndiaye, D. and Denning, D. W. (2015) ‘Burden of fungal infections in Senegal.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Beardsley, J., Denning, D. W., Chau, N. V., Yen, N. T., Crump, J. A. and Day, J. N. (2015) ‘Estimating the burden of fungal disease in Vietnam.’ Mycoses. 2015/10/10, 58 Suppl 5. [PubMed]
Ben, R. and Denning, D. W. (2015) ‘Estimating the Burden of Fungal Diseases in Israel.’ The Israel Medical Association journal : IMAJ. 2015/08/04, 17(6). [Source]
Brasier, A. R., Zhao, Y., Spratt, H. M., Wiktorowicz, J. E., Ju, H., Wheat, L. J., Baden, L., Stafford, S., Wu, Z., Issa, N., Caliendo, A. M., Denning, D. W., Soman, K., Clancy, C. J., Nguyen, M. H., Sugrue, M. W., Alexander, B. D. and Wingard, J. R. (2015) ‘Improved Detection of Invasive Pulmonary Aspergillosis Arising during Leukemia Treatment Using a Panel of Host Response Proteins and Fungal Antigens.’ PloS one. 2015/11/19, 10(11). [PubMed]
Chishimba, L., Langridge, P., Powell, G., Niven, R. M. and Denning, D. W. (2015) ‘Efficacy and safety of nebulised amphotericin B (NAB) in severe asthma with fungal sensitisation (SAFS) and allergic bronchopulmonary aspergillosis (ABPA).’ The Journal of asthma : official journal of the Association for the Care of Asthma. 2014/08/27, 52(3). [Source]
Chrdle, A., Mallatova, N., Vasakova, M., Haber, J. and Denning, D. W. (2015) ‘Burden of serious fungal infections in the Czech Republic.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Corzo-Leon, D. E., Armstrong-James, D. and Denning, D. W. (2015) ‘Burden of serious fungal infections in Mexico.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Denning, D. W. (2015) ‘The ambitious “95-95 by 2025” roadmap for the diagnosis and management of fungal diseases.’ Thorax. 2015/05/31, 70(7). [Source]
Denning, D. W. and Bromley, M. J. (2015) ‘Infectious Disease. How to bolster the antifungal pipeline.’ Science. 2015/03/31, 347(6229). [Source]
Denning, D. W., Ghnan, N., Kwizera, R. and Osmanov, A. (2015) ‘Comment on: Susceptibility breakpoints and target values for therapeutic drug monitoring of voriconazole and Aspergillus fumigatus in an in vitro pharmacokinetic/pharmacodynamic model.’ The Journal of antimicrobial chemotherapy. 2014/08/26, 70(2). [Source]
Denning, D. W. and Gugnani, H. C. (2015) ‘Burden of serious fungal infections in Trinidad and Tobago.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Dorgan, E., Denning, D. W. and McMullan, R. (2015) ‘Burden of fungal disease in Ireland.’ Journal of medical microbiology. 2015/01/18, 64(Pt 4). [Source]
Faini, D., Maokola, W., Furrer, H., Hatz, C., Battegay, M., Tanner, M., Denning, D. W. and Letang, E. (2015) ‘Burden of serious fungal infections in Tanzania.’ Mycoses. 2015/10/10, 58 Suppl 5(AL, Barcelona Ctr. Int. Health Res (CRESIB), Hospital Clinic-Universitat de Barcelona, Barcelona, Spain.). [Source]
Gugnani, H. C. and Denning, D. W. (2015) ‘Estimated Burden of Serious Fungal Infections in Jamaica by Literature Review and Modelling.’ The West Indian medical journal. 2015/10/02, 64(3). [PubMed]
Hedayati, M. T., Azimi, Y., Droudinia, A., Mousavi, B., Khalilian, A., Hedayati, N. and Denning, D. W. (2015) ‘Prevalence of chronic pulmonary aspergillosis in patients with tuberculosis from Iran.’ European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2015/05/25, 34(9). [Source]
de Hoog, G. S., Chaturvedi, V., Denning, D. W., Dyer, P. S., Frisvad, J. C., Geiser, D., Graser, Y., Guarro, J., Haase, G., Kwon-Chung, K. J., Meis, J. F., Meyer, W., Pitt, J. I., Samson, R. A., Taylor, J. W., Tintelnot, K., Vitale, R. G., Walsh, T. J. and Lackner, M. (2015) ‘Name changes in medically important fungi and their implications for clinical practice.’ Journal of clinical microbiology. 2014/10/10, 53(Working Group on Nomenclature of Medical Fungi). [PubMed]
Khwakhali, U. S. and Denning, D. W. (2015) ‘Burden of serious fungal infections in Nepal.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Klimko, N., Kozlova, Y., Khostelidi, S., Shadrivova, O., Borzova, Y., Burygina, E., Vasilieva, N. and Denning, D. W. (2015) ‘The burden of serious fungal diseases in Russia.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Kosmidis, C. and Denning, D. W. (2015a) ‘Republished: The clinical spectrum of pulmonary aspergillosis.’ Postgraduate medical journal. 2015/07/19, 91(1077). [Source]
Kosmidis, C. and Denning, D. W. (2015b) ‘The clinical spectrum of pulmonary aspergillosis.’ Thorax. 2014/10/31, 70(3). [Source]
Kosmidis, C., Powell, G., Borrow, R., Morris, J., Alachkar, H. and Denning, D. W. (2015) ‘Response to pneumococcal polysaccharide vaccination in patients with chronic and allergic aspergillosis.’ Vaccine. 2015/11/08, 33(51). [Source]
Lagrou, K., Maertens, J., Van Even, E. and Denning, D. W. (2015) ‘Burden of serious fungal infections in Belgium.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
van der Linden, J. W., Arendrup, M. C., Warris, A., Lagrou, K., Pelloux, H., Hauser, P. M., Chryssanthou, E., Mellado, E., Kidd, S. E., Tortorano, A. M., Dannaoui, E., Gaustad, P., Baddley, J. W., Uekotter, A., Lass-Florl, C., Klimko, N., Moore, C. B., Denning, D. W., Pasqualotto, A. C., Kibbler, C., Arikan-Akdagli, S., Andes, D., Meletiadis, J., Naumiuk, L., Nucci, M., Melchers, W. J. and Verweij, P. E. (2015) ‘Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.’ Emerging infectious diseases. 2015/05/20, 21(6). [PubMed]
Lowes, D., Chishimba, L., Greaves, M. and Denning, D. W. (2015) ‘Development of chronic pulmonary aspergillosis in adult asthmatics with ABPA.’ Respiratory medicine. 2015/10/29, 109(12). [Source]
Mortensen, K. L., Denning, D. W. and Arendrup, M. C. (2015) ‘The burden of fungal disease in Denmark.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Osmanov, A. and Denning, D. W. (2015) ‘Burden of serious fungal infections in Ukraine.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Page, I. D., Richardson, M. D. and Denning, D. W. (2016) ‘Comparison of six Aspergillus-specific IgG assays for the diagnosis of chronic pulmonary aspergillosis (CPA).’ The Journal of infection. 2015/12/19, 72(2). [Source]
Page, I. D., Richardson, M. and Denning, D. W. (2015) ‘Antibody testing in aspergillosis–quo vadis?’ Medical mycology. 2015/05/17, 53(5). [Source]
Parkes-Ratanshi, R., Achan, B., Kwizera, R., Kambugu, A., Meya, D. and Denning, D. W. (2015) ‘Cryptococcal disease and the burden of other fungal diseases in Uganda; Where are the knowledge gaps and how can we fill them?’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Rodriguez-Tudela, J. L., Alastruey-Izquierdo, A., Gago, S., Cuenca-Estrella, M., Leon, C., Miro, J. M., Nunez Boluda, A., Ruiz Camps, I., Sole, A. and Denning, D. W. (2015) ‘Burden of serious fungal infections in Spain.’ Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2015/02/07, 21(2). [Source]
Ruhnke, M., Groll, A. H., Mayser, P., Ullmann, A. J., Mendling, W., Hof, H. and Denning, D. W. (2015) ‘Estimated burden of fungal infections in Germany.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Schelenz, S., Barnes, R. A., Barton, R. C., Cleverley, J. R., Lucas, S. B., Kibbler, C. C. and Denning, D. W. (2015) ‘British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases.’ The Lancet. Infectious diseases. 2015/03/17, 15(4). [Source]
Sili, U., Bilgin, H., Masania, R., Eryuksel, E., Cimsit, N. C., Ayranci, G., Richardson, M. and Korten, V. (2015) ‘Successful treatment of an invasive fungal infection caused by Talaromyces sp. with voriconazole.’ Medical mycology case reports. 2015/04/02, 8. [PubMed]
Sinko, J., Sulyok, M. and Denning, D. W. (2015) ‘Burden of serious fungal diseases in Hungary.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Smith, N. L., Bromley, M. J., Denning, D. W., Simpson, A. and Bowyer, P. (2015) ‘Elevated levels of the neutrophil chemoattractant pro-platelet basic protein in macrophages from individuals with chronic and allergic aspergillosis.’ The Journal of infectious diseases. 2014/09/07, 211(4). [Source]
Taj-Aldeen, S. J., Chandra, P. and Denning, D. W. (2015) ‘Burden of fungal infections in Qatar.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Thomas, S., Hassan, I., Barker, J., Ashworth, A., Barnes, A., Fedor, I., Feddy, L., Hayes, T., Malagon, I., Stirling, S., Szentgyorgyi, L., Mutton, K. and Richardson, M. (2015) ‘Chronic mould exposure as a risk factor for severe community acquired pneumonia in a patient requiring extra corporeal membrane oxygenation.’ Respiratory medicine case reports. 2015/08/04, 15. [PubMed]
Verweij, P. E., Ananda-Rajah, M., Andes, D., Arendrup, M. C., Bruggemann, R. J., Chowdhary, A., Cornely, O. A., Denning, D. W., Groll, A. H., Izumikawa, K., Kullberg, B. J., Lagrou, K., Maertens, J., Meis, J. F., Newton, P., Page, I., Seyedmousavi, S., Sheppard, D. C., Viscoli, C., Warris, A. and Donnelly, J. P. (2015) ‘International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus.’ Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 2015/08/19, 21–22. [Source]

2014

Agarwal, R., Denning, D. W. and Chakrabarti, A. (2014) ‘Estimation of the burden of chronic and allergic pulmonary aspergillosis in India.’ PloS one. 2014/12/06, 9(12). [PubMed]
Armstead, J., Morris, J. and Denning, D. W. (2014) ‘Multi-country estimate of different manifestations of aspergillosis in cystic fibrosis.’ PloS one. 2014/06/11, 9(6). [PubMed]
Barnes, R. A., Gow, N. A., Denning, D. W., May, R. C. and Haynes, K. (2014) ‘Antifungal resistance: more research needed.’ Lancet. 2014/11/13, 384(9952). [Source]
Bowyer, P. and Denning, D. W. (2014) ‘Environmental fungicides and triazole resistance in Aspergillus.’ Pest management science. 2013/04/26, 70(2). [Source]
Denning, D. W., Pashley, C., Hartl, D., Wardlaw, A., Godet, C., Del Giacco, S., Delhaes, L. and Sergejeva, S. (2014) ‘Fungal allergy in asthma-state of the art and research needs.’ Clinical and translational allergy. 2014/04/17, 4. [PubMed]
Ellenbogen, J. R., Waqar, M., Denning, D. W., Cooke, R. P., Skinner, D. W., Lesser, T. and Javadpour, M. (2014) ‘Posaconazole responsive cerebral aspergillosis in an immunocompetent adult.’ Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2014/06/19, 21(10). [Source]
Fraczek, M. G., Kirwan, M. B., Moore, C. B., Morris, J., Denning, D. W. and Richardson, M. D. (2014) ‘Volume dependency for culture of fungi from respiratory secretions and increased sensitivity of Aspergillus quantitative PCR.’ Mycoses. 2013/06/22, 57(2). [Source]
Hudson, L. N., Newbold, T., Contu, S., Hill, S. L., Lysenko, I., De Palma, A., Phillips, H. R., Senior, R. A., Bennett, D. J., Booth, H., Choimes, A., Correia, D. L., Day, J., Echeverria-Londono, S., Garon, M., Harrison, M. L., Ingram, D. J., Jung, M., Kemp, V., Kirkpatrick, L., Martin, C. D., Pan, Y., White, H. J., Aben, J., Abrahamczyk, S., Adum, G. B., Aguilar-Barquero, V., Aizen, M. A., Ancrenaz, M., Arbelaez-Cortes, E., Armbrecht, I., Azhar, B., Azpiroz, A. B., Baeten, L., Baldi, A., Banks, J. E., Barlow, J., Batary, P., Bates, A. J., Bayne, E. M., Beja, P., Berg, A., Berry, N. J., Bicknell, J. E., Bihn, J. H., Bohning-Gaese, K., Boekhout, T., Boutin, C., Bouyer, J., Brearley, F. Q., Brito, I., Brunet, J., Buczkowski, G., Buscardo, E., Cabra-Garcia, J., Calvino-Cancela, M., Cameron, S. A., Cancello, E. M., Carrijo, T. F., Carvalho, A. L., Castro, H., Castro-Luna, A. A., Cerda, R., Cerezo, A., Chauvat, M., Clarke, F. M., Cleary, D. F., Connop, S. P., D’Aniello, B., da Silva, P. G., Darvill, B., Dauber, J., Dejean, A., Diekotter, T., Dominguez-Haydar, Y., Dormann, C. F., Dumont, B., Dures, S. G., Dynesius, M., Edenius, L., Elek, Z., Entling, M. H., Farwig, N., Fayle, T. M., Felicioli, A., Felton, A. M., Ficetola, G. F., Filgueiras, B. K., Fonte, S. J., Fraser, L. H., Fukuda, D., Furlani, D., Ganzhorn, J. U., Garden, J. G., Gheler-Costa, C., Giordani, P., Giordano, S., Gottschalk, M. S., Goulson, D. and Gove, A. D. (2014) ‘The PREDICTS database: a global database of how local terrestrial biodiversity responds to human impacts.’ odiversity Chair, C. (ed.) Ecology and evolution. 2015/01/06, 4(24). [PubMed]
Jones, A. M., Horsley, A. and Denning, D. W. (2014) ‘What is the importance of classifying Aspergillus disease in cystic fibrosis patients?’ Expert review of respiratory medicine. 2014/05/30, 8(4). [Source]
Marttila, E., Jarvensivu, A., Sorsa, T., Grenier, D., Richardson, M., Kari, K., Tervahartiala, T. and Rautemaa, R. (2014) ‘Intracellular localization of Treponema denticola chymotrypsin-like proteinase in chronic periodontitis.’ Journal of oral microbiology. 2014/07/10, 6. [PubMed]
Muldoon, E. G. and Denning, D. W. (2014) ‘Editorial commentary: Prophylactic echinocandin: is there a subgroup of intensive care unit patients who benefit?’ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2014/02/20, 58(9). [Source]
Nowaseb, V., Gaeb, E., Fraczek, M. G., Richardson, M. D. and Denning, D. W. (2014) ‘Frequency of Pneumocystis jirovecii in sputum from HIV and TB patients in Namibia.’ Journal of infection in developing countries. 2014/03/13, 8(3). [Source]
Oladele, R. O. and Denning, D. W. (2014) ‘Burden of serious fungal infection in Nigeria.’ West African journal of medicine. 2014/09/23, 33(2). [Source]
Smith, N. L. and Denning, D. W. (2014) ‘Clinical implications of interferon-gamma genetic and epigenetic variants.’ Immunology. 2014/07/24, 143(4). [PubMed]
Smith, N. L., Hankinson, J., Simpson, A., Bowyer, P. and Denning, D. W. (2014) ‘A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary aspergillosis.’ Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2013/11/28, 20(8). [Source]
Smith, N. L., Hankinson, J., Simpson, A., Denning, D. W. and Bowyer, P. (2014) ‘Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT.’ Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2014/04/10, 20(11). [Source]
Zumla, A., Memish, Z. A., Maeurer, M., Bates, M., Mwaba, P., Al-Tawfiq, J. A., Denning, D. W., Hayden, F. G. and Hui, D. S. (2014) ‘Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options.’ The Lancet. Infectious diseases. 2014/09/06, 14(11). [Source]

2013

Agarwal, R., Chakrabarti, A., Shah, A., Gupta, D., Meis, J. F., Guleria, R., Moss, R. and Denning, D. W. (2013) ‘Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria.’ Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2013/07/31, 43(8). [Source]
Al-Shair, K., Atherton, G. T., Harris, C., Ratcliffe, L., Newton, P. J. and Denning, D. W. (2013) ‘Long-term antifungal treatment improves health status in patients with chronic pulmonary aspergillosis: a longitudinal analysis.’ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2013/06/22, 57(6). [PubMed]
Al-shair, K., Atherton, G. T., Kennedy, D., Powell, G., Denning, D. W. and Caress, A. (2013) ‘Validity and reliability of the St. George’s Respiratory Questionnaire in assessing health status in patients with chronic pulmonary aspergillosis.’ Chest. 2012/11/29, 144(2). [Source]
Baxter, C. G., Denning, D. W., Jones, A. M., Todd, A., Moore, C. B. and Richardson, M. D. (2013) ‘Performance of two Aspergillus IgG EIA assays compared with the precipitin test in chronic and allergic aspergillosis.’ Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2013/01/22, 19(4). [Source]
Baxter, C. G., Dunn, G., Jones, A. M., Webb, K., Gore, R., Richardson, M. D. and Denning, D. W. (2013) ‘Novel immunologic classification of aspergillosis in adult cystic fibrosis.’ The Journal of allergy and clinical immunology. 2013/06/04, 132(3). [Source]
Baxter, C. G., Moore, C. B., Jones, A. M., Webb, A. K. and Denning, D. W. (2013) ‘IgE-mediated immune responses and airway detection of Aspergillus and Candida in adult cystic fibrosis.’ Chest. 2012/11/10, 143(5). [Source]
Baxter, C. G., Rautemaa, R., Jones, A. M., Webb, A. K., Bull, M., Mahenthiralingam, E. and Denning, D. W. (2013) ‘Intravenous antibiotics reduce the presence of Aspergillus in adult cystic fibrosis sputum.’ Thorax. 2013/03/21, 68(7). [Source]
Bowyer, P. and Denning, D. W. (2014) ‘Environmental fungicides and triazole resistance in Aspergillus.’ Pest management science. 2013/04/26, 70(2). [Source]
Buied, A., Moore, C. B., Denning, D. W. and Bowyer, P. (2013) ‘High-level expression of cyp51B in azole-resistant clinical Aspergillus fumigatus isolates.’ The Journal of antimicrobial chemotherapy. 2012/12/05, 68(3). [Source]
Denning, D. W. and Bowyer, P. (2013) ‘Voriconazole resistance in Aspergillus fumigatus: should we be concerned?’ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2013/05/15, 57(4). [PubMed]
Denning, D. W., Pleuvry, A. and Cole, D. C. (2013a) ‘Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults.’ Medical mycology. 2012/12/06, 51(4). [Source]
Denning, D. W., Pleuvry, A. and Cole, D. C. (2013b) ‘Global burden of chronic pulmonary aspergillosis complicating sarcoidosis.’ The European respiratory journal. 2012/06/30, 41(3). [Source]
Farid, S., Mohamed, S., Devbhandari, M., Kneale, M., Richardson, M., Soon, S. Y., Jones, M. T., Krysiak, P., Shah, R., Denning, D. W. and Rammohan, K. (2013) ‘Results of surgery for chronic pulmonary Aspergillosis, optimal antifungal therapy and proposed high risk factors for recurrence–a National Centre’s experience.’ Journal of cardiothoracic surgery. 2013/08/07, 8. [PubMed]
Fraczek, M. G., Bromley, M., Buied, A., Moore, C. B., Rajendran, R., Rautemaa, R., Ramage, G., Denning, D. W. and Bowyer, P. (2013) ‘The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus.’ The Journal of antimicrobial chemotherapy. 2013/04/13, 68(7). [Source]
Fraczek, M. G., Kirwan, M. B., Moore, C. B., Morris, J., Denning, D. W. and Richardson, M. D. (2014) ‘Volume dependency for culture of fungi from respiratory secretions and increased sensitivity of Aspergillus quantitative PCR.’ Mycoses. 2013/06/22, 57(2). [Source]
Hayes, G. E. and Denning, D. W. (2013) ‘Frequency, diagnosis and management of fungal respiratory infections.’ Current opinion in pulmonary medicine. 2013/02/16, 19(3). [Source]
Haylett, A. K., Felton, S., Denning, D. W. and Rhodes, L. E. (2013) ‘Voriconazole-induced photosensitivity: photobiological assessment of a case series of 12 patients.’ The British journal of dermatology. 2012/08/07, 168(1). [Source]
Howard, S. J., Pasqualotto, A. C., Anderson, M. J., Leatherbarrow, H., Albarrag, A. M., Harrison, E., Gregson, L., Bowyer, P. and Denning, D. W. (2013) ‘Major variations in Aspergillus fumigatus arising within aspergillomas in chronic pulmonary aspergillosis.’ Mycoses. 2013/02/02, 56(4). [Source]

2012

Aquino, V. R., Nagel, F., Andreolla, H. F., de-Paris, F., Xavier, M. O., Goldani, L. Z., Denning, D. W. and Pasqualotto, A. C. (2012) ‘The performance of real-time PCR, galactomannan, and fungal culture in the diagnosis of invasive aspergillosis in ventilated patients with chronic obstructive pulmonary disease (COPD).’ Mycopathologia. 2012/03/03, 174(2). [Source]
Bowyer, P., Mosquera, J., Anderson, M., Birch, M., Bromley, M. and Denning, D. W. (2012) ‘Identification of novel genes conferring altered azole susceptibility in Aspergillus fumigatus.’ FEMS microbiology letters. 2012/04/19, 332(1). [PubMed]
Brown, G. D., Denning, D. W., Gow, N. A., Levitz, S. M., Netea, M. G. and White, T. C. (2012) ‘Hidden killers: human fungal infections.’ Science translational medicine. 2012/12/21, 4(165). [Source]
Brown, G. D., Denning, D. W. and Levitz, S. M. (2012) ‘Tackling human fungal infections.’ Science. 2012/05/15, 336(6082). [Source]
Buied, A., Moore, C. B., Denning, D. W. and Bowyer, P. (2013) ‘High-level expression of cyp51B in azole-resistant clinical Aspergillus fumigatus isolates.’ The Journal of antimicrobial chemotherapy. 2012/12/05, 68(3). [Source]
Chishimba, L., Niven, R. M., Cooley, J. and Denning, D. W. (2012) ‘Voriconazole and posaconazole improve asthma severity in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization.’ The Journal of asthma : official journal of the Association for the Care of Asthma. 2012/03/03, 49(4). [Source]
Chrdle, A., Mustakim, S., Bright-Thomas, R. J., Baxter, C. G., Felton, T. and Denning, D. W. (2012) ‘Aspergillus bronchitis without significant immunocompromise.’ Annals of the New York Academy of Sciences. 2012/12/13, 1272. [Source]
Denning, D. W., Pleuvry, A. and Cole, D. C. (2013a) ‘Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults.’ Medical mycology. 2012/12/06, 51(4). [Source]
Denning, D. W., Pleuvry, A. and Cole, D. C. (2013b) ‘Global burden of chronic pulmonary aspergillosis complicating sarcoidosis.’ The European respiratory journal. 2012/06/30, 41(3). [Source]
Gould, F. K., Denning, D. W., Elliott, T. S., Foweraker, J., Perry, J. D., Prendergast, B. D., Sandoe, J. A., Spry, M. J., Watkin, R. W. and Working Party of the British Society for Antimicrobial, C. (2012) ‘Guidelines for the diagnosis and antibiotic treatment of endocarditis in adults: a report of the Working Party of the British Society for Antimicrobial Chemotherapy.’ The Journal of antimicrobial chemotherapy. 2011/11/17, 67(2). [Source]
Harrison, E., Singh, A., Morris, J., Smith, N. L., Fraczek, M. G., Moore, C. B. and Denning, D. W. (2012) ‘Mannose-binding lectin genotype and serum levels in patients with chronic and allergic pulmonary aspergillosis.’ International journal of immunogenetics. 2012/01/10, 39(3). [PubMed]
Haylett, A. K., Felton, S., Denning, D. W. and Rhodes, L. E. (2013) ‘Voriconazole-induced photosensitivity: photobiological assessment of a case series of 12 patients.’ The British journal of dermatology. 2012/08/07, 168(1). [Source]
Joardar, V., Abrams, N. F., Hostetler, J., Paukstelis, P. J., Pakala, S., Pakala, S. B., Zafar, N., Abolude, O. O., Payne, G., Andrianopoulos, A., Denning, D. W. and Nierman, W. C. (2012) ‘Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.’ BMC genomics. 2012/12/14, 13. [PubMed]
Knutsen, A. P., Bush, R. K., Demain, J. G., Denning, D. W., Dixit, A., Fairs, A., Greenberger, P. A., Kariuki, B., Kita, H., Kurup, V. P., Moss, R. B., Niven, R. M., Pashley, C. H., Slavin, R. G., Vijay, H. M. and Wardlaw, A. J. (2012) ‘Fungi and allergic lower respiratory tract diseases.’ The Journal of allergy and clinical immunology. 2012/01/31, 129(2). [Source]
Pendleton, M. and Denning, D. W. (2012) ‘Multifocal pulmonary aspergillomas: case series and review.’ Annals of the New York Academy of Sciences. 2012/12/13, 1272. [Source]
Singh, B. and Denning, D. W. (2012) ‘Allergic bronchopulmonary mycosis due to Alternaria: Case report and review.’ Medical mycology case reports. 2012/01/01, 1(1). [PubMed]

2011

Adamama-Moraitou, K. K., Pardali, D., Day, M. J., Denning, D. W., Papazoglou, L., Papastefanou, A. and Rallis, T. S. (2011) ‘Aspergillus fumigatus Bronchopneumonia in a Hellenic Shepherd Dog.’ Journal of the American Animal Hospital Association. 2011/03/02, 47(2). [Source]
Albarrag, A. M., Anderson, M. J., Howard, S. J., Robson, G. D., Warn, P. A., Sanglard, D. and Denning, D. W. (2011) ‘Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter.’ Antimicrobial agents and chemotherapy. 2011/08/31, 55(11). [PubMed]
Baxter, C. G., Bishop, P., Low, S. E., Baiden-Amissah, K. and Denning, D. W. (2011) ‘Pulmonary aspergillosis: an alternative diagnosis to lung cancer after positive [18F]FDG positron emission tomography.’ Thorax. 2011/04/05, 66(7). [Source]
Baxter, C. G., Jones, A. M., Webb, K. and Denning, D. W. (2011) ‘Homogenisation of cystic fibrosis sputum by sonication–an essential step for Aspergillus PCR.’ Journal of microbiological methods. 2011/02/01, 85(1). [Source]
Baxter, C. G., Marshall, A., Roberts, M., Felton, T. W. and Denning, D. W. (2011) ‘Peripheral neuropathy in patients on long-term triazole antifungal therapy.’ The Journal of antimicrobial chemotherapy. 2011/06/21, 66(9). [Source]
Bowyer, P., Moore, C. B., Rautemaa, R., Denning, D. W. and Richardson, M. D. (2011) ‘Azole antifungal resistance today: focus on Aspergillus.’ Current infectious disease reports. 2011/09/21, 13(6). [Source]
Denning, D. W., Park, S., Lass-Florl, C., Fraczek, M. G., Kirwan, M., Gore, R., Smith, J., Bueid, A., Moore, C. B., Bowyer, P. and Perlin, D. S. (2011) ‘High-frequency triazole resistance found In nonculturable Aspergillus fumigatus from lungs of patients with chronic fungal disease.’ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2011/04/07, 52(9). [PubMed]
Denning, D. W. and Perlin, D. S. (2011) ‘Azole resistance in Aspergillus: a growing public health menace.’ Future microbiology. 2011/11/16, 6(11). [Source]
Denning, D. W., Pleuvry, A. and Cole, D. C. (2011) ‘Global burden of chronic pulmonary aspergillosis as a sequel to pulmonary tuberculosis.’ Bulletin of the World Health Organization. 2012/01/25, 89(12). [PubMed]
Gargani, Y., Bishop, P. and Denning, D. W. (2011) ‘Too many mouldy joints – marijuana and chronic pulmonary aspergillosis.’ Mediterranean journal of hematology and infectious diseases. 2011/06/01, 3(1). [PubMed]
Gould, F. K., Denning, D. W., Elliott, T. S., Foweraker, J., Perry, J. D., Prendergast, B. D., Sandoe, J. A., Spry, M. J., Watkin, R. W. and Working Party of the British Society for Antimicrobial, C. (2012) ‘Guidelines for the diagnosis and antibiotic treatment of endocarditis in adults: a report of the Working Party of the British Society for Antimicrobial Chemotherapy.’ The Journal of antimicrobial chemotherapy. 2011/11/17, 67(2). [Source]
Hauser, P. M., Bille, J., Lass-Florl, C., Geltner, C., Feldmesser, M., Levi, M., Patel, H., Muggia, V., Alexander, B., Hughes, M., Follett, S. A., Cui, X., Leung, F., Morgan, G., Moody, A., Perlin, D. S. and Denning, D. W. (2011) ‘Multicenter, prospective clinical evaluation of respiratory samples from subjects at risk for Pneumocystis jirovecii infection by use of a commercial real-time PCR assay.’ Journal of clinical microbiology. 2011/03/04, 49(5). [PubMed]
Hogan, C. and Denning, D. W. (2011) ‘Allergic bronchopulmonary aspergillosis and related allergic syndromes.’ Seminars in respiratory and critical care medicine. 2011/12/15, 32(6). [Source]
Howard, S. J., Harrison, E., Bowyer, P., Varga, J. and Denning, D. W. (2011) ‘Cryptic species and azole resistance in the Aspergillus niger complex.’ Antimicrobial agents and chemotherapy. 2011/07/20, 55(10). [PubMed]
Karadi, R. L., Gow, D., Kellett, M., Denning, D. W. and O’Driscoll, R. B. (2011) ‘Itraconazole associated quadriparesis and edema: a case report.’ Journal of medical case reports. 2011/04/12, 5. [PubMed]
Lass-Florl, C., Follett, S. A., Moody, A. and Denning, D. W. (2011) ‘Detection of Aspergillus in lung and other tissue samples using the MycAssay Aspergillus real-time PCR kit.’ Canadian journal of microbiology. 2011/08/25, 57(9). [Source]
Purcell, J., McKenna, J., Critten, P., Denning, D. W. and Hassan, I. A. (2011) ‘Mixed mould species in laboratory cultures of respiratory specimens: how should they be reported, and what are the indications for susceptibility testing?’ Journal of clinical pathology. 2011/01/11, 64(6). [Source]
Slater, J. L., Gregson, L., Denning, D. W. and Warn, P. A. (2011) ‘Pathogenicity of Aspergillus fumigatus mutants assessed in Galleria mellonella matches that in mice.’ Medical mycology. 2010/10/19, 49 Suppl 1. [Source]
Smith, N. L. and Denning, D. W. (2011) ‘Underlying conditions in chronic pulmonary aspergillosis including simple aspergilloma.’ The European respiratory journal. 2010/07/03, 37(4). [Source]
Tuckwell, D., Denning, D. W. and Bowyer, P. (2011) ‘A public resource for metabolic pathway mapping of Aspergillus fumigatus Af293.’ Medical mycology. 2010/05/29, 49 Suppl 1. [Source]

2010

Bueid, A., Howard, S. J., Moore, C. B., Richardson, M. D., Harrison, E., Bowyer, P. and Denning, D. W. (2010) ‘Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009.’ The Journal of antimicrobial chemotherapy. 2010/08/24, 65(10). [Source]
Carvalho, A., Cunha, C., Pasqualotto, A. C., Pitzurra, L., Denning, D. W. and Romani, L. (2010) ‘Genetic variability of innate immunity impacts human susceptibility to fungal diseases.’ International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2009/10/16, 14(6). [Source]
Chai, L. Y., Denning, D. W. and Warn, P. (2010) ‘Candida tropicalis in human disease.’ Critical reviews in microbiology. 2010/10/05, 36(4). [Source]
Dannaoui, E., Schwarz, P., Slany, M., Loeffler, J., Jorde, A. T., Cuenca-Estrella, M., Hauser, P. M., Shrief, R., Huerre, M., Freiberger, T., Gaustad, P., Rodriguez-Tudela, J. L., Bille, J., Denning, D. W., Bretagne, S. and Lortholary, O. (2010) ‘Molecular detection and identification of zygomycetes species from paraffin-embedded tissues in a murine model of disseminated zygomycosis: a collaborative European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection Study Group (EFISG) evaluation.’ Journal of clinical microbiology. 2010/04/09, 48(6). [PubMed]
Denning, D. W. and Hope, W. W. (2010) ‘Therapy for fungal diseases: opportunities and priorities.’ Trends in microbiology. 2010/03/09, 18(5). [Source]
Felton, T. W., Baxter, C., Moore, C. B., Roberts, S. A., Hope, W. W. and Denning, D. W. (2010) ‘Efficacy and safety of posaconazole for chronic pulmonary aspergillosis.’ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2010/11/09, 51(12). [Source]
Felton, T. W., Plested, V., Walsham, A., Dark, P., O’Driscoll, R. and Denning, D. W. (2010) ‘A 27-year-old woman with acute, severe asthma who developed respiratory failure.’ Chest. 2010/03/06, 137(3). [Source]
Fraczek, M. G., Rashid, R., Denson, M., Denning, D. W. and Bowyer, P. (2010) ‘Aspergillus fumigatus allergen expression is coordinately regulated in response to hydrogen peroxide and cyclic AMP.’ Clinical and molecular allergy : CMA. 2010/11/05, 8. [PubMed]
Harrison, E., Stalhberger, T., Whelan, R., Sugrue, M., Wingard, J. R., Alexander, B. D., Follett, S. A., Bowyer, P. and Denning, D. W. (2010) ‘Aspergillus DNA contamination in blood collection tubes.’ Diagnostic microbiology and infectious disease. 2010/07/20, 67(4). [PubMed]
Hedayati, M. T., Mayahi, S. and Denning, D. W. (2010) ‘A study on Aspergillus species in houses of asthmatic patients from Sari City, Iran and a brief review of the health effects of exposure to indoor Aspergillus.’ Environmental monitoring and assessment. 2009/08/22, 168(1–4). [Source]
Hiemenz, J. W., Raad, I., Maertens, J. A., Hachem, R. Y., Saah, A. J., Sable, C. A., Chodakewitz, J. A., Severino, M. E., Saddier, P., Berman, R. S., Ryan, D. M., Dinubile, M. J., Patterson, T. F., Denning, D. W. and Walsh, T. J. (2010) ‘Efficacy of caspofungin as salvage therapy for invasive aspergillosis compared to standard therapy in a historical cohort.’ European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2010/08/13, 29(11). [Source]
Howard, S. J., Pasqualotto, A. C. and Denning, D. W. (2010) ‘Azole resistance in allergic bronchopulmonary aspergillosis and Aspergillus bronchitis.’ Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2009/08/14, 16(6). [Source]
Lestner, J. M. and Denning, D. W. (2010) ‘Tremor: a newly described adverse event with long-term itraconazole therapy.’ Journal of neurology, neurosurgery, and psychiatry. 2010/02/27, 81(3). [Source]
Slater, J. L., Gregson, L., Denning, D. W. and Warn, P. A. (2011) ‘Pathogenicity of Aspergillus fumigatus mutants assessed in Galleria mellonella matches that in mice.’ Medical mycology. 2010/10/19, 49 Suppl 1. [Source]
Smith, N. L. and Denning, D. W. (2011) ‘Underlying conditions in chronic pulmonary aspergillosis including simple aspergilloma.’ The European respiratory journal. 2010/07/03, 37(4). [Source]
Tuckwell, D., Denning, D. W. and Bowyer, P. (2011) ‘A public resource for metabolic pathway mapping of Aspergillus fumigatus Af293.’ Medical mycology. 2010/05/29, 49 Suppl 1. [Source]
Warn, P. A., Sharp, A., Morrissey, G. and Denning, D. W. (2010) ‘Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus.’ International journal of antimicrobial agents. 2009/12/18, 35(2). [Source]