In 2018/19, most of the FIT’s activity was devoted to health professional education, public outreach and research. The FIT website (www.fungalinfectiontrust.org) averaged 3,000 to 5,500 unique visitors per month in 2018-19 (low estimate based on server access), visitors coming overwhelmingly (approx. 90%) from the US.

Online education in fungal microscopy and histology (www.microfungi.net/)

The FIT has extended the world’s first online Microscopy and Histology course (www.microfungi.net), with Module 4 (histopathology of rare fungi) now translated into French, Spanish and Portuguese alongside Modules 1-3.  Translations of Module 4 were launched in February 2019. In June 2019, there are 1205 (up from 756 in 2018) registered users in 119 countries on Microfungi.net logging in up to 16 times per day and recording over 50,000 activity records per month. Users can refer to the course materials indefinitely, even if they have completed all the modules and received their certificates.
160 learners are registered to use the translated Modules. Certificates are not awarded for the introductory Module 1 but 143 have been awarded for Module 2, 175 for Module 3 and 26 for Module 4 as of June 2019, a total of 344.

The Aspergillus Website (www.aspergillus.org.uk)

The Aspergillus Website remains the world’s most comprehensive resource for the pathogenic and allergenic fungi Aspergillus and the diseases that they cause. It is completely free to all users. It is supported from the UK National Health Service and unrestricted educational grants from various corporate donors, notably Mayne Pharma, Pfizer, Dynamiker, Gilead and Zambon.

The comprehensive list of drugs and drug interactions with antifungals is continually updated, and now includes the drug interaction database (including the antifungal drug interaction app for apple and android phones) is popular and well used.

Current monthly figures show that 100,000 – 130,000 individual computers accessed The Aspergillus Website and Patients’ Website alone per month, 5,000 to 8,000 people daily. This equates to 8.5 million ‘requests for content’.

Mapping of www.aspergillus.org.uk (see figure below for 2019 figures, darker shading = more users) shows that The Website reaches people in over 147 countries. USA is the country from which we get most visits with UK and India in the next 2 places, France and China in 4th & 5th place respectively.

Patients’ Website (aspergillosis.org)

The Patients Website has had a complete refresh in 2019 which includes moving it to a new domain name aspergillosis.org.  Megan Bridgeland, a University of Manchester student for a year adopted this website as her project and as part of her studies has converted this website to act as the centre of a community rather than a static information resource. This was important as our communities has expanded enormously since the old website was built in 2012.

Many patients and carers use online support discussion groups and the FIT supports these people in several ways:

  • Our (Facebook) worldwide communities are very active with >3,000 participants engaging 5000 times per month (https://www.facebook.com/groups/aspergillussupport/),
  • The NHS Choices (Now NHS online) online community is no longer hosted on NHS website but has over 2000 members
  • Local online Facebook groups (30 groups, 11 in the UK serving 684 people)
  • Facebook group specifically for carers (158 members) (https://www.facebook.com/groups/aspergillosis.carers/)
  • The Professional LinkedIn members (Aspergillus and Aspergillosis Group) has over 530 members.

The provision of live and recorded online events held by the National Aspergillosis Centre, happening on a monthly basis are now hosted within the Facebook communities and generally get >500 viewers each month.

Leading International Fungal Education (LIFE) (www.LIFE-Worldwide.org)

The FIT continues to support the expansion of the educational brand LIFE, a summary website with key information of fungi causing disease, the most important fungal diseases, causative fungi, diagnostic tests (including skin allergy tests and imaging), and antifungal therapies, in English and Spanish.

It presents information in two main formats:

  • Bite-sized summaries, to be used as an introductory overview or quick reference
  • Recorded lectures on clinical topics of a quality commensurate with a MSc course, hosted on YouTube

Static content is available in both English and Spanish, and includes focused summaries of the main diseases, treatments, diagnostics and causative agents, as well as continuously-updated listings of treatment guidelines and commercial diagnostics (including direct links to suppliers).

Website traffic for LIFE Worldwide has almost doubled over the past year, from 10,100 in April 2018 to 19,900 in April 2019 (Google Analytics).

LIFE has recently become more active on Twitter, particularly by retweeting key papers as they come out and promoting out new content with multiple-choice quiz questions to test participants’ clinical knowledge. There are currently 600 followers, growing at a rate of around 30 per month.

Around half of our user base in 2019 is made up of visitors from the US (~24%), India (~15%), Mexico (6%) and the UK (5%). Other countries making up a small minority (1-5%) of our users include the Spain, Argentina, Nigeria, Colombia, and Peru. NOTE outside the UK, US and India a lot of these countries are predominantly Spanish speaking.

A component of the LIFE effort was to boost public awareness of fungal infections generally. This has involved estimating the burden of serious fungal disease in over 84 countries, to highlight the seriousness of a range of primary and secondary fungal diseases. Additions since last year’s report are underlined.

  • Published in journals (x59): Algeria, Argentina, Austria, Bangladesh, Belgium, Brazil, Burkina FasoCameroon, Canada, Chile, Colombia, Czech Republic, Denmark, Dominican Republic, Ecuador, Egypt, France, Germany, Ghana, Greece, Guatemala, Hungary, India, Iran, Ireland, Israel, Italy, Jamaica, Jordan, Kazakhstan, Kenya, MalawiMalaysia, Mexico, Mozambique, Nepal, Nigeria, Norway, Pakistan, Peru, Philippines, Portugal, Qatar, Romania, Russia, Senegal, Serbia, Spain, Sri Lanka, Tanzania, Thailand, Trinidad and Tobago, Turkey, Uganda, UK, Ukraine, Uruguay, Uzbekistan and Vietnam. Published burden papers are available at https://www.gaffi.org/media/academic-papers/.
  • Presented in abstract/poster form at conferences but not yet published (x22): Australia, Belarus, Benin, China, Congo, Ethiopia, Iraq, Indonesia, Japan, Madagascar, Mongolia, Namibia, Netherlands, New Zealand, Paraguay, Saudi Arabia, Singapore, South Africa, Sweden, Taiwan, Venezuela, Zambia (copies are available on the LIFE website in the news section http://www.life-worldwide.org/media-centre/news)

The FIT also supported a number of interesting and significant findings. There were 24 peer-reviewed publications in calendar year 2018 as a direct consequence of FIT  grants, burden of fungal disease estimates (as above) and infrastructure support in prior years and are shown in Appendix 1. The notable outputs include:

  • The first review of the occurrence of histoplasmosis in Africa.
  • Multiple country burden of disease estimates
  • A review of Aspergillus nail infections – probably totalling >10 million worldwide
  • Modelling of the frequency of recurrent thrush (yeast infection) in women – numbering >130 million affected globally
  • A human mutation (ZNF77) that greatly allows Aspergillus to grow in the human airway
  • Confirmation of the link with being a carrier of cystic fibrosis and ABPA
  • The fungi found in the airways of people with ABPA and severe asthma and its increase related to corticosteroid therapy

During the year support was given to New Hope Specialist Hospital in Ghana and to the AIDS related Mycoses Conference in Cape Town South Africa. In addition Travel and Living Allowance Grants for attendance and presentation at scientific conferences totalling £4,952 (2018 £6,424) were made during the year as part of the Trust’s policy to support scientists in the early stages of their careers in mycology. Support was also given to an independent body, the Aspergillus Trust, £4,279, in their efforts to promote awareness of Aspergillosis. This included £2,160 towards the cost of a bus poster campaign in London. In return the Aspergillus Trust have raised donations of £5,929 for the FIT.

Listing of papers generated with the support of FIT

2018

Bassetti M, Carnelutti A, Peghin M, Aversa F, Barchiesi F, Girmenia C, Pagano L, Sanguinetti M, Tortorano AM, Montagna MT, Viale P, Viscoli C, Denning DW. Estimated burden of fungal infections in Italy. J Infect 2018;76:103–106.
Oladele R, Ayanlowo OO, Richardson MD, Denning DW. Histoplasmosis in Africa: An emerging or a neglected disease? PLoS Negl Trop Dis 2018;12: e0006046.
Wadi J, Denning DW. Burden of serious fungal infections in Jordan. J Fungi 2018; 4:15.
Nordøy I, Liv Hesstvedt L, Andersen CT, Mylvaganam H, Kols NI, Falch BM, Tofteland S, Müller F, Denning DW. An estimate of the burden of fungal disease in Norway. J Fungi 2018; 4:29.
Mares M, Moroti-Constantinescu VR, Denning DW. The burden of fungal diseases in Romania. J Fungi 2018; 4:31.
Kemaykin VM, Tabinbaev NB, Khudaibergenova MS, Olifirovich AA, Abdrakhmanova LM, Denning DW, Klimko N. Severe and chronic fungal diseases in the Republic of Kazakhstan. J Fungi 2018;4:34.
Bamba S, Zida A, Sangaré I, Cissé M, Denning DW, Hennequin C. Burden of severe fungal infections in Burkina Faso. J Fungi 2018;4:35.
Macedo-Viñas M, Denning DW. Estimating the burden of serious fungal infections in Uruguay. J Fungi 2018; 4:37.
Velayuthan RD, Samudi C, Kaur H, Ng KP, Denning DW, Shankar EM. Estimation of burden of serious human fungal infections in Malaysia. J Fungi 2018;4:38.
Alvarez-Moreno CA, Cortes CA, Denning DW. Burden of fungal infections in Colombia. J Fungi 2018;4:41.
Overton NLD, Denning DW, Bowyer P. Mutations in EEA1 are associated with allergic bronchopulmonary aspergillosis and affect phagocytosis of Aspergillus fumigatus by human macrophages. PLoS ONE 2018;13:
Bongomin F, Harris C, Hayes G, Kosmidis C, Denning DW. Twelve month outcomes of 206 patients with chronic pulmonary aspergillosis. PLoS One 2018;13:
Mandengue C, Denning DW. The burden of serious fungal infections in Cameroon. J Fungi 2018;4:E44.
Riera FO, Caeiro JP, Denning DW. Burden of serious fungal Infections in Argentina. J Fungi 2018;4:51.
Bongomin F, Batac C, Richardson MD, Denning DW. Aspergillus onychomycosis: Mycology and epidemiology. Mycopathologia 2018;183:485-93.
Kalua K, Zimba B, Denning DW. Estimated burden of serious fungal diseases in Malawi. J Fungi 2018;4:61.
Sacarlal J, Denning DW. Estimated burden of serious fungal diseases in Mozambique. J Fungi 2018;4:75.
Arsic Arsenijivek V, Denning DW. Estimated burden of serious fungal diseases in Serbia. J Fungi 2018;4:76.
Denning DW. Page ID, Chakaya J, Jabeen K, Jude CM, Cornet M, Alastruey-Izquierdo A, Bongomin F, Bowyer P, Chakrabarti A, Gago S, Guto J, Hochhegger B, Hoenigl M, Irfan M, Irurhe N, Izumikawa K, Kirenga B, Manduku V, Moazam S, Oladele RO, Richardson MD, Rodriguez TudelaJL, Rozaliyani A, Salzer HJF, Sawyer R, Simukulwa NF, Skrahina A, Sriruttan C, Setianingrum F, Wilopo BAP, Cole DC, Getahun H. Case definition of chronic pulmonary aspergillosis in resource-constrained settings. Emerg Infect Dis 2018;24(8).
Denning DW, Kneale M, Rautemaa-Richardson R, Sobel JD. Global burden of recurrent vulvovaginal candidiasis. Lancet Infect Dis 2018;18:e339-e347.
Gago S, Ben Ghazzi N, Overton NLD, Denning DW, Bowyer P. The human ZNF77 transcription factor controls Aspergillus fumigatus load at the bronchial epithelium. Nat Communications 2018;9:3835.
Gamaletsou MN, Hayes GE, Harris C, Muldoon EG, Brock J, Denning DW. F508del CFTR gene mutation in patients with allergic bronchopulmonary aspergillosis. J Asthma 2018;55:837-43.
Fraczek MG, Chishimba L, Niven RM, Simpson A, Smyth L, Denning DW, Bowyer P. Corticosteroid treatment is associated with increased filamentous fungal burden in airways. J Allergy Clin Immunol 2018;142:407-414.
Hedayati MT, Armaki MT, Jamshid, Charati Y, Hedayati N, Seyedmousavi S, Denning DW. Burden of fungal infections in Iran. J Infect Dis Dev Ctries 2018; 12:910-18.

2017

Pegorie M, Denning DW, Welfare W. Estimating the burden of invasive and serious fungal disease in the UK. J Infect 2017;74:60-71.
Denning DW, Perlin DS, Muldoon EG, Colombo AL, Chakrabarti A, Richardson MD, Sorrell TC. Delivering on the antimicrobial resistance agenda not possible without improving fungal diagnostic capabilities. Emerg Infect Dis 2017;23:177-183.
Bustamante B, Denning DW, Campos PE. Estimating the burden of fungal infections in the Peruvian population. Eur J Clin Microbiol Infect Dis 2017;36:943-8.
Zaki SM, Denning DW. The burden of serious fungal diseases in Egypt. Eur J Clin Microbiol Infect Dis 2017;36:971-86.
Dufresne SF, Sheppard DC, Cole DC, Denning DC. Estimating the burden of serious fungal diseases in Canada. Eur J Clin Microbiol Infect Dis 2017;36:987-92.
Chayakulkeeree M, Denning DW. Estimating the burden of serious fungal diseases in Thailand. Eur J Clin Microbiol Infect Dis 2017;36:931-5.
Jabeen K, Farooqi J, Mirza M, Denning DW, Zafar A. Estimated burden of serious fungal infections in Pakistan. Eur J Clin Microbiol Infect Dis 2017;36:949-56.
Medina N, Samayoa B, Lau-Bonilla D, Denning DW, Herrera R, Mercado D, Guzmán B, Figueroa L, Pérez JC, Arathoon E. Burden of serious fungal infections in Guatemala. Eur J Clin Microbiol Infect Dis 2017;36:965-69.
Denning DW. Calling upon all public health mycologists. (Editorial) Eur J Clin Microbiol Infect Dis 2017;36:923-4.
Lowes D, Al-Shair K, Newton PJ, Morris J, Harris C, Rautemaa-Richardson R, Denning DW. Baseline parameters of survival in chronic pulmonary aspergillosis. Eur Resp J 2017;49:1601062.
Gugnani H, Denning DW, Rahim R, Sadat A, Belal M, Mahbub S. The estimated burden of serious fungal infections in Bangladesh. Eur J Clin Microbiol Infect Dis 2017;36:993-7.
Duarte EA, Denning DW. Estimating the burden of serious fungal infections in Chile. Eur J Clin Microbiol Infect Dis 2017;36:983-6
Chekiri-Talbi M, Denning DW. Burden of fungal infections in Algeria. Eur J Clin Microbiol Infect Dis 2017;36:999-1004. [French translation in J Mycol Med 2017; 27:139-145] Huh K, Ha EY, Denning DW, Peck KR. Estimating the burden of fungal disease in Korea. Eur J Clin Microbiol Infect Dis 2017;36:957-63.
Tilavberdiev SA, Denning DW, Klimko NN. Serious fungal diseases in the Republic of Uzbekistan. Eur J Clin Microbiol Infect Dis 2017;36:925-929.
Zurita J, Denning DW, Paz-Y-Miño A, Solís MB, Arias LM. Serious fungal infections in Ecuador. Eur J Clin Microbiol Infect Dis 2017;36:975-981.
Batac MCR, Denning D. Serious fungal infections in the Philippines. Eur J Clin Microbiol Infect Dis 2017;36:937-941.
Sabino R, Verissímo C, Brandão J, Martins C, Alves D, Pais C, Denning DW. Serious fungal infections in Portugal. Eur J Clin Microbiol Infect Dis 2017;36:1345-1352.
McCarthy MW, Denning DW, Walsh TJ. Future research priorities in fungal resistance. J Infect Dis 2017;64:986-7.
Overton NLD, Simpson A, Bowyer P, Denning DW. Genetic susceptibility to severe asthma with fungal sensitisation. Int J Immunogenet 2017;44:93-106.
Oladele R, Bongomin F, Gago S, Denning DW. HIV-Associated Cryptococcal Disease in Resource-Limited Settings: A Case for “Prevention Is Better Than Cure”? J Fungi 2017: 3, 67.
Bongomin F, Harris C, Foden P, Kosmidis C, Denning DW. Innate and adaptive immune defects in chronic pulmonary aspergillosis. J of Fungi 2017;2:26.
Kwizera R, Parkes Ratanshi R, Page ID, Wiltshire CS, Musaazi J, Fehr J, Castelnuovo B, Kambugu A, Denning DW. Elevated Aspergillus-specific antibody levels among HIV infected Ugandans with pulmonary tuberculosis. BMC Pulm Med 2017;17:149.
Maghrabi F, Denning DW. The management of chronic pulmonary aspergillosis: The UK National Aspergillosis Centre approach. Curr Fungal Infect Rep 2017;11:242-251.
Bongomin F, Gago S, Oladele RO, Denning DW. Global and national prevalence of fungal diseases – Estimate precision. J Fungi 2017; 3:E57.
Jiménez-Ortigosa C, Moore C, Denning DW, Perlin DS. Emergence of echinocandin resistance due to a point mutation in the fks1 gene of Aspergillus fumigatus in a patient with chronic pulmonary aspergillosis. Antimicrob Agents Chemother 2017;61:e01277-17.
Moore CB, Novak-Frazer L, Muldoon E, Dunn KW, Masania R, Richardson M, Rautemaa-Richardson R. First isolation of the pan-azole-resistant Aspergillus fumigatus cyp51A TR46/Y121F/T289A mutant in a UK patient. Int J Antimicrob Agents 2017, 49: 512-514.
Perlin DS, Rautemaa-Richardson R, Alastruey-Izquierdo A. The global problem of antifungal resistance: prevalence, mechanisms, and management. Lancet Infect Dis 2017;17:e383-e392.
Overton N, Gago S, Bowyer P. Immunogenetics of Chronic and Allergic Aspergillosis. In Carvalho A, editor, Immunogenetics of Fungal Diseases. Springer. 2017. p. 153-171.

2016

Al-Shair, K., Muldoon, E. G., Morris, J., Atherton, G. T., Kosmidis, C. and Denning, D. W. (2016) ‘Characterisation of fatigue and its substantial impact on health status in a large cohort of patients with chronic pulmonary aspergillosis (CPA).’ Respiratory medicine. 2016/04/26, 114. [Source]
Bartholomew, J. S., Banfield, S., Atherton, G. T. and Denning, D. W. (2016) ‘Comment on: Antifungal therapy: drug-drug interactions at your fingertips.’ The Journal of antimicrobial chemotherapy. 2016/03/06, 71(7). [Source]
Bromley, M., Johns, A., Davies, E., Fraczek, M., Mabey Gilsenan, J., Kurbatova, N., Keays, M., Kapushesky, M., Gut, M., Gut, I., Denning, D. W. and Bowyer, P. (2016) ‘Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi.’ PloS one. 2016/07/22, 11(7). [PubMed]
Denning, D. W., Cadranel, J., Beigelman-Aubry, C., Ader, F., Chakrabarti, A., Blot, S., Ullmann, A. J., Dimopoulos, G. and Lange, C. (2016) ‘Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management.’ The European respiratory journal. 2015/12/25, 47(1). [Source]
Gamaletsou, M. N., Drogari-Apiranthitou, M., Denning, D. W. and Sipsas, N. V. (2016) ‘An estimate of the burden of serious fungal diseases in Greece.’ European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2016/04/18, 35(7). [Source]
Gamaletsou, M. N., Rammaert, B., Bueno, M. A., Sipsas, N. V., Moriyama, B., Kontoyiannis, D. P., Roilides, E., Zeller, V., Taj-Aldeen, S. J., Henry, M., Petraitis, V., Denning, D. W., Lortholary, O. and Walsh, T. J. (2016) ‘Aspergillus arthritis: analysis of clinical manifestations, diagnosis, and treatment of 31 reported cases.’ Medical mycology. 2016/09/10. [Source]
Giacomazzi, J., Baethgen, L., Carneiro, L. C., Millington, M. A., Denning, D. W., Colombo, A. L. and Pasqualotto, A. C. (2016) ‘The burden of serious human fungal infections in Brazil.’ Mycoses. 2015/12/23, 59(3). [Source]
Gugnani, H. C. and Denning, D. W. (2016) ‘Burden of serious fungal infections in the Dominican Republic.’ Journal of infection and public health. 2015/06/02, 9(1). [Source]
Guto, J. A., Bii, C. C. and Denning, D. W. (2016) ‘Estimated burden of fungal infections in Kenya.’ Journal of infection in developing countries. 2016/09/01, 10(8). [Source]
Kneale, M., Bartholomew, J. S., Davies, E. and Denning, D. W. (2016) ‘Global access to antifungal therapy and its variable cost.’ The Journal of antimicrobial chemotherapy. 2016/08/16. [Source]
Langridge, P. J., Sheehan, R. L. and Denning, D. W. (2016) ‘Microbial yield from physiotherapy assisted sputum production in respiratory outpatients.’ BMC pulmonary medicine. 2016/02/03, 16. [PubMed]
Muldoon, E. G., Sharman, A., Page, I., Bishop, P. and Denning, D. W. (2016) ‘Aspergillus nodules; another presentation of Chronic Pulmonary Aspergillosis.’ BMC pulmonary medicine. 2016/08/20, 16(1). [PubMed]
Newton, P. J., Harris, C., Morris, J. and Denning, D. W. (2016) ‘Impact of liposomal amphotericin B therapy on chronic pulmonary aspergillosis.’ The Journal of infection. 2016/07/05. [Source]
Oladele, R. O., Akanmu, A. S., Nwosu, A. O., Ogunsola, F. T., Richardson, M. D. and Denning, D. W. (2016) ‘Cryptococcal Antigenemia in Nigerian Patients With Advanced Human Immunodeficiency Virus: Influence of Antiretroviral Therapy Adherence.’ Open forum infectious diseases. 2016/05/18, 3(2). [PubMed]
Page, I. D., Richardson, M. D. and Denning, D. W. (2016) ‘Comparison of six Aspergillus-specific IgG assays for the diagnosis of chronic pulmonary aspergillosis (CPA).’ The Journal of infection. 2015/12/19, 72(2). [Source]
Patterson, T. F., Thompson, G. R., Denning, D. W., Fishman, J. A., Hadley, S., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Nguyen, M. H., Segal, B. H., Steinbach, W. J., Stevens, D. A., Walsh, T. J., Wingard, J. R., Young, J. A. and Bennett, J. E. (2016a) ‘Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America.’ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2016/08/03, 63(4). [PubMed]
Patterson, T. F., Thompson, G. R., Denning, D. W., Fishman, J. A., Hadley, S., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Nguyen, M. H., Segal, B. H., Steinbach, W. J., Stevens, D. A., Walsh, T. J., Wingard, J. R., Young, J. A. and Bennett, J. E. (2016b) ‘Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America.’ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2016/07/02, 63(4). [PubMed]
Sintes, M., De Moliner, F., Caballero-Lima, D., Denning, D. W., Read, N. D., Kielland, N., Vendrell, M. and Lavilla, R. (2016) ‘Electrophilic, Activation-Free Fluorogenic Reagent for Labeling Bioactive Amines.’ Bioconjugate chemistry. 2016/06/02, 27(6). [Source]

2015

Badiane, A. S., Ndiaye, D. and Denning, D. W. (2015) ‘Burden of fungal infections in Senegal.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Beardsley, J., Denning, D. W., Chau, N. V., Yen, N. T., Crump, J. A. and Day, J. N. (2015) ‘Estimating the burden of fungal disease in Vietnam.’ Mycoses. 2015/10/10, 58 Suppl 5. [PubMed]
Ben, R. and Denning, D. W. (2015) ‘Estimating the Burden of Fungal Diseases in Israel.’ The Israel Medical Association journal : IMAJ. 2015/08/04, 17(6). [Source]
Brasier, A. R., Zhao, Y., Spratt, H. M., Wiktorowicz, J. E., Ju, H., Wheat, L. J., Baden, L., Stafford, S., Wu, Z., Issa, N., Caliendo, A. M., Denning, D. W., Soman, K., Clancy, C. J., Nguyen, M. H., Sugrue, M. W., Alexander, B. D. and Wingard, J. R. (2015) ‘Improved Detection of Invasive Pulmonary Aspergillosis Arising during Leukemia Treatment Using a Panel of Host Response Proteins and Fungal Antigens.’ PloS one. 2015/11/19, 10(11). [PubMed]
Chishimba, L., Langridge, P., Powell, G., Niven, R. M. and Denning, D. W. (2015) ‘Efficacy and safety of nebulised amphotericin B (NAB) in severe asthma with fungal sensitisation (SAFS) and allergic bronchopulmonary aspergillosis (ABPA).’ The Journal of asthma : official journal of the Association for the Care of Asthma. 2014/08/27, 52(3). [Source]
Chrdle, A., Mallatova, N., Vasakova, M., Haber, J. and Denning, D. W. (2015) ‘Burden of serious fungal infections in the Czech Republic.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Corzo-Leon, D. E., Armstrong-James, D. and Denning, D. W. (2015) ‘Burden of serious fungal infections in Mexico.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Denning, D. W. (2015) ‘The ambitious “95-95 by 2025” roadmap for the diagnosis and management of fungal diseases.’ Thorax. 2015/05/31, 70(7). [Source]
Denning, D. W. and Bromley, M. J. (2015) ‘Infectious Disease. How to bolster the antifungal pipeline.’ Science. 2015/03/31, 347(6229). [Source]
Denning, D. W., Ghnan, N., Kwizera, R. and Osmanov, A. (2015) ‘Comment on: Susceptibility breakpoints and target values for therapeutic drug monitoring of voriconazole and Aspergillus fumigatus in an in vitro pharmacokinetic/pharmacodynamic model.’ The Journal of antimicrobial chemotherapy. 2014/08/26, 70(2). [Source]
Denning, D. W. and Gugnani, H. C. (2015) ‘Burden of serious fungal infections in Trinidad and Tobago.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Dorgan, E., Denning, D. W. and McMullan, R. (2015) ‘Burden of fungal disease in Ireland.’ Journal of medical microbiology. 2015/01/18, 64(Pt 4). [Source]
Faini, D., Maokola, W., Furrer, H., Hatz, C., Battegay, M., Tanner, M., Denning, D. W. and Letang, E. (2015) ‘Burden of serious fungal infections in Tanzania.’ Mycoses. 2015/10/10, 58 Suppl 5(AL, Barcelona Ctr. Int. Health Res (CRESIB), Hospital Clinic-Universitat de Barcelona, Barcelona, Spain.). [Source]
Gugnani, H. C. and Denning, D. W. (2015) ‘Estimated Burden of Serious Fungal Infections in Jamaica by Literature Review and Modelling.’ The West Indian medical journal. 2015/10/02, 64(3). [PubMed]
Hedayati, M. T., Azimi, Y., Droudinia, A., Mousavi, B., Khalilian, A., Hedayati, N. and Denning, D. W. (2015) ‘Prevalence of chronic pulmonary aspergillosis in patients with tuberculosis from Iran.’ European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2015/05/25, 34(9). [Source]
de Hoog, G. S., Chaturvedi, V., Denning, D. W., Dyer, P. S., Frisvad, J. C., Geiser, D., Graser, Y., Guarro, J., Haase, G., Kwon-Chung, K. J., Meis, J. F., Meyer, W., Pitt, J. I., Samson, R. A., Taylor, J. W., Tintelnot, K., Vitale, R. G., Walsh, T. J. and Lackner, M. (2015) ‘Name changes in medically important fungi and their implications for clinical practice.’ Journal of clinical microbiology. 2014/10/10, 53(Working Group on Nomenclature of Medical Fungi). [PubMed]
Khwakhali, U. S. and Denning, D. W. (2015) ‘Burden of serious fungal infections in Nepal.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Klimko, N., Kozlova, Y., Khostelidi, S., Shadrivova, O., Borzova, Y., Burygina, E., Vasilieva, N. and Denning, D. W. (2015) ‘The burden of serious fungal diseases in Russia.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Kosmidis, C. and Denning, D. W. (2015a) ‘Republished: The clinical spectrum of pulmonary aspergillosis.’ Postgraduate medical journal. 2015/07/19, 91(1077). [Source]
Kosmidis, C. and Denning, D. W. (2015b) ‘The clinical spectrum of pulmonary aspergillosis.’ Thorax. 2014/10/31, 70(3). [Source]
Kosmidis, C., Powell, G., Borrow, R., Morris, J., Alachkar, H. and Denning, D. W. (2015) ‘Response to pneumococcal polysaccharide vaccination in patients with chronic and allergic aspergillosis.’ Vaccine. 2015/11/08, 33(51). [Source]
Lagrou, K., Maertens, J., Van Even, E. and Denning, D. W. (2015) ‘Burden of serious fungal infections in Belgium.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
van der Linden, J. W., Arendrup, M. C., Warris, A., Lagrou, K., Pelloux, H., Hauser, P. M., Chryssanthou, E., Mellado, E., Kidd, S. E., Tortorano, A. M., Dannaoui, E., Gaustad, P., Baddley, J. W., Uekotter, A., Lass-Florl, C., Klimko, N., Moore, C. B., Denning, D. W., Pasqualotto, A. C., Kibbler, C., Arikan-Akdagli, S., Andes, D., Meletiadis, J., Naumiuk, L., Nucci, M., Melchers, W. J. and Verweij, P. E. (2015) ‘Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.’ Emerging infectious diseases. 2015/05/20, 21(6). [PubMed]
Lowes, D., Chishimba, L., Greaves, M. and Denning, D. W. (2015) ‘Development of chronic pulmonary aspergillosis in adult asthmatics with ABPA.’ Respiratory medicine. 2015/10/29, 109(12). [Source]
Mortensen, K. L., Denning, D. W. and Arendrup, M. C. (2015) ‘The burden of fungal disease in Denmark.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Osmanov, A. and Denning, D. W. (2015) ‘Burden of serious fungal infections in Ukraine.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Page, I. D., Richardson, M. D. and Denning, D. W. (2016) ‘Comparison of six Aspergillus-specific IgG assays for the diagnosis of chronic pulmonary aspergillosis (CPA).’ The Journal of infection. 2015/12/19, 72(2). [Source]
Page, I. D., Richardson, M. and Denning, D. W. (2015) ‘Antibody testing in aspergillosis–quo vadis?’ Medical mycology. 2015/05/17, 53(5). [Source]
Parkes-Ratanshi, R., Achan, B., Kwizera, R., Kambugu, A., Meya, D. and Denning, D. W. (2015) ‘Cryptococcal disease and the burden of other fungal diseases in Uganda; Where are the knowledge gaps and how can we fill them?’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Rodriguez-Tudela, J. L., Alastruey-Izquierdo, A., Gago, S., Cuenca-Estrella, M., Leon, C., Miro, J. M., Nunez Boluda, A., Ruiz Camps, I., Sole, A. and Denning, D. W. (2015) ‘Burden of serious fungal infections in Spain.’ Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2015/02/07, 21(2). [Source]
Ruhnke, M., Groll, A. H., Mayser, P., Ullmann, A. J., Mendling, W., Hof, H. and Denning, D. W. (2015) ‘Estimated burden of fungal infections in Germany.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Schelenz, S., Barnes, R. A., Barton, R. C., Cleverley, J. R., Lucas, S. B., Kibbler, C. C. and Denning, D. W. (2015) ‘British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases.’ The Lancet. Infectious diseases. 2015/03/17, 15(4). [Source]
Sili, U., Bilgin, H., Masania, R., Eryuksel, E., Cimsit, N. C., Ayranci, G., Richardson, M. and Korten, V. (2015) ‘Successful treatment of an invasive fungal infection caused by Talaromyces sp. with voriconazole.’ Medical mycology case reports. 2015/04/02, 8. [PubMed]
Sinko, J., Sulyok, M. and Denning, D. W. (2015) ‘Burden of serious fungal diseases in Hungary.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Smith, N. L., Bromley, M. J., Denning, D. W., Simpson, A. and Bowyer, P. (2015) ‘Elevated levels of the neutrophil chemoattractant pro-platelet basic protein in macrophages from individuals with chronic and allergic aspergillosis.’ The Journal of infectious diseases. 2014/09/07, 211(4). [Source]
Taj-Aldeen, S. J., Chandra, P. and Denning, D. W. (2015) ‘Burden of fungal infections in Qatar.’ Mycoses. 2015/10/10, 58 Suppl 5. [Source]
Thomas, S., Hassan, I., Barker, J., Ashworth, A., Barnes, A., Fedor, I., Feddy, L., Hayes, T., Malagon, I., Stirling, S., Szentgyorgyi, L., Mutton, K. and Richardson, M. (2015) ‘Chronic mould exposure as a risk factor for severe community acquired pneumonia in a patient requiring extra corporeal membrane oxygenation.’ Respiratory medicine case reports. 2015/08/04, 15. [PubMed]
Verweij, P. E., Ananda-Rajah, M., Andes, D., Arendrup, M. C., Bruggemann, R. J., Chowdhary, A., Cornely, O. A., Denning, D. W., Groll, A. H., Izumikawa, K., Kullberg, B. J., Lagrou, K., Maertens, J., Meis, J. F., Newton, P., Page, I., Seyedmousavi, S., Sheppard, D. C., Viscoli, C., Warris, A. and Donnelly, J. P. (2015) ‘International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus.’ Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 2015/08/19, 21–22. [Source]

2014

Agarwal, R., Denning, D. W. and Chakrabarti, A. (2014) ‘Estimation of the burden of chronic and allergic pulmonary aspergillosis in India.’ PloS one. 2014/12/06, 9(12). [PubMed]
Armstead, J., Morris, J. and Denning, D. W. (2014) ‘Multi-country estimate of different manifestations of aspergillosis in cystic fibrosis.’ PloS one. 2014/06/11, 9(6). [PubMed]
Barnes, R. A., Gow, N. A., Denning, D. W., May, R. C. and Haynes, K. (2014) ‘Antifungal resistance: more research needed.’ Lancet. 2014/11/13, 384(9952). [Source]
Bowyer, P. and Denning, D. W. (2014) ‘Environmental fungicides and triazole resistance in Aspergillus.’ Pest management science. 2013/04/26, 70(2). [Source]
Denning, D. W., Pashley, C., Hartl, D., Wardlaw, A., Godet, C., Del Giacco, S., Delhaes, L. and Sergejeva, S. (2014) ‘Fungal allergy in asthma-state of the art and research needs.’ Clinical and translational allergy. 2014/04/17, 4. [PubMed]
Ellenbogen, J. R., Waqar, M., Denning, D. W., Cooke, R. P., Skinner, D. W., Lesser, T. and Javadpour, M. (2014) ‘Posaconazole responsive cerebral aspergillosis in an immunocompetent adult.’ Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2014/06/19, 21(10). [Source]
Fraczek, M. G., Kirwan, M. B., Moore, C. B., Morris, J., Denning, D. W. and Richardson, M. D. (2014) ‘Volume dependency for culture of fungi from respiratory secretions and increased sensitivity of Aspergillus quantitative PCR.’ Mycoses. 2013/06/22, 57(2). [Source]
Hudson, L. N., Newbold, T., Contu, S., Hill, S. L., Lysenko, I., De Palma, A., Phillips, H. R., Senior, R. A., Bennett, D. J., Booth, H., Choimes, A., Correia, D. L., Day, J., Echeverria-Londono, S., Garon, M., Harrison, M. L., Ingram, D. J., Jung, M., Kemp, V., Kirkpatrick, L., Martin, C. D., Pan, Y., White, H. J., Aben, J., Abrahamczyk, S., Adum, G. B., Aguilar-Barquero, V., Aizen, M. A., Ancrenaz, M., Arbelaez-Cortes, E., Armbrecht, I., Azhar, B., Azpiroz, A. B., Baeten, L., Baldi, A., Banks, J. E., Barlow, J., Batary, P., Bates, A. J., Bayne, E. M., Beja, P., Berg, A., Berry, N. J., Bicknell, J. E., Bihn, J. H., Bohning-Gaese, K., Boekhout, T., Boutin, C., Bouyer, J., Brearley, F. Q., Brito, I., Brunet, J., Buczkowski, G., Buscardo, E., Cabra-Garcia, J., Calvino-Cancela, M., Cameron, S. A., Cancello, E. M., Carrijo, T. F., Carvalho, A. L., Castro, H., Castro-Luna, A. A., Cerda, R., Cerezo, A., Chauvat, M., Clarke, F. M., Cleary, D. F., Connop, S. P., D’Aniello, B., da Silva, P. G., Darvill, B., Dauber, J., Dejean, A., Diekotter, T., Dominguez-Haydar, Y., Dormann, C. F., Dumont, B., Dures, S. G., Dynesius, M., Edenius, L., Elek, Z., Entling, M. H., Farwig, N., Fayle, T. M., Felicioli, A., Felton, A. M., Ficetola, G. F., Filgueiras, B. K., Fonte, S. J., Fraser, L. H., Fukuda, D., Furlani, D., Ganzhorn, J. U., Garden, J. G., Gheler-Costa, C., Giordani, P., Giordano, S., Gottschalk, M. S., Goulson, D. and Gove, A. D. (2014) ‘The PREDICTS database: a global database of how local terrestrial biodiversity responds to human impacts.’ odiversity Chair, C. (ed.) Ecology and evolution. 2015/01/06, 4(24). [PubMed]
Jones, A. M., Horsley, A. and Denning, D. W. (2014) ‘What is the importance of classifying Aspergillus disease in cystic fibrosis patients?’ Expert review of respiratory medicine. 2014/05/30, 8(4). [Source]
Marttila, E., Jarvensivu, A., Sorsa, T., Grenier, D., Richardson, M., Kari, K., Tervahartiala, T. and Rautemaa, R. (2014) ‘Intracellular localization of Treponema denticola chymotrypsin-like proteinase in chronic periodontitis.’ Journal of oral microbiology. 2014/07/10, 6. [PubMed]
Muldoon, E. G. and Denning, D. W. (2014) ‘Editorial commentary: Prophylactic echinocandin: is there a subgroup of intensive care unit patients who benefit?’ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2014/02/20, 58(9). [Source]
Nowaseb, V., Gaeb, E., Fraczek, M. G., Richardson, M. D. and Denning, D. W. (2014) ‘Frequency of Pneumocystis jirovecii in sputum from HIV and TB patients in Namibia.’ Journal of infection in developing countries. 2014/03/13, 8(3). [Source]
Oladele, R. O. and Denning, D. W. (2014) ‘Burden of serious fungal infection in Nigeria.’ West African journal of medicine. 2014/09/23, 33(2). [Source]
Smith, N. L. and Denning, D. W. (2014) ‘Clinical implications of interferon-gamma genetic and epigenetic variants.’ Immunology. 2014/07/24, 143(4). [PubMed]
Smith, N. L., Hankinson, J., Simpson, A., Bowyer, P. and Denning, D. W. (2014) ‘A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary aspergillosis.’ Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2013/11/28, 20(8). [Source]
Smith, N. L., Hankinson, J., Simpson, A., Denning, D. W. and Bowyer, P. (2014) ‘Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT.’ Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2014/04/10, 20(11). [Source]
Zumla, A., Memish, Z. A., Maeurer, M., Bates, M., Mwaba, P., Al-Tawfiq, J. A., Denning, D. W., Hayden, F. G. and Hui, D. S. (2014) ‘Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options.’ The Lancet. Infectious diseases. 2014/09/06, 14(11). [Source]

2013

Agarwal, R., Chakrabarti, A., Shah, A., Gupta, D., Meis, J. F., Guleria, R., Moss, R. and Denning, D. W. (2013) ‘Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria.’ Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2013/07/31, 43(8). [Source]
Al-Shair, K., Atherton, G. T., Harris, C., Ratcliffe, L., Newton, P. J. and Denning, D. W. (2013) ‘Long-term antifungal treatment improves health status in patients with chronic pulmonary aspergillosis: a longitudinal analysis.’ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2013/06/22, 57(6). [PubMed]
Al-shair, K., Atherton, G. T., Kennedy, D., Powell, G., Denning, D. W. and Caress, A. (2013) ‘Validity and reliability of the St. George’s Respiratory Questionnaire in assessing health status in patients with chronic pulmonary aspergillosis.’ Chest. 2012/11/29, 144(2). [Source]
Baxter, C. G., Denning, D. W., Jones, A. M., Todd, A., Moore, C. B. and Richardson, M. D. (2013) ‘Performance of two Aspergillus IgG EIA assays compared with the precipitin test in chronic and allergic aspergillosis.’ Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2013/01/22, 19(4). [Source]
Baxter, C. G., Dunn, G., Jones, A. M., Webb, K., Gore, R., Richardson, M. D. and Denning, D. W. (2013) ‘Novel immunologic classification of aspergillosis in adult cystic fibrosis.’ The Journal of allergy and clinical immunology. 2013/06/04, 132(3). [Source]
Baxter, C. G., Moore, C. B., Jones, A. M., Webb, A. K. and Denning, D. W. (2013) ‘IgE-mediated immune responses and airway detection of Aspergillus and Candida in adult cystic fibrosis.’ Chest. 2012/11/10, 143(5). [Source]
Baxter, C. G., Rautemaa, R., Jones, A. M., Webb, A. K., Bull, M., Mahenthiralingam, E. and Denning, D. W. (2013) ‘Intravenous antibiotics reduce the presence of Aspergillus in adult cystic fibrosis sputum.’ Thorax. 2013/03/21, 68(7). [Source]
Bowyer, P. and Denning, D. W. (2014) ‘Environmental fungicides and triazole resistance in Aspergillus.’ Pest management science. 2013/04/26, 70(2). [Source]
Buied, A., Moore, C. B., Denning, D. W. and Bowyer, P. (2013) ‘High-level expression of cyp51B in azole-resistant clinical Aspergillus fumigatus isolates.’ The Journal of antimicrobial chemotherapy. 2012/12/05, 68(3). [Source]
Denning, D. W. and Bowyer, P. (2013) ‘Voriconazole resistance in Aspergillus fumigatus: should we be concerned?’ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2013/05/15, 57(4). [PubMed]
Denning, D. W., Pleuvry, A. and Cole, D. C. (2013a) ‘Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults.’ Medical mycology. 2012/12/06, 51(4). [Source]
Denning, D. W., Pleuvry, A. and Cole, D. C. (2013b) ‘Global burden of chronic pulmonary aspergillosis complicating sarcoidosis.’ The European respiratory journal. 2012/06/30, 41(3). [Source]
Farid, S., Mohamed, S., Devbhandari, M., Kneale, M., Richardson, M., Soon, S. Y., Jones, M. T., Krysiak, P., Shah, R., Denning, D. W. and Rammohan, K. (2013) ‘Results of surgery for chronic pulmonary Aspergillosis, optimal antifungal therapy and proposed high risk factors for recurrence–a National Centre’s experience.’ Journal of cardiothoracic surgery. 2013/08/07, 8. [PubMed]
Fraczek, M. G., Bromley, M., Buied, A., Moore, C. B., Rajendran, R., Rautemaa, R., Ramage, G., Denning, D. W. and Bowyer, P. (2013) ‘The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus.’ The Journal of antimicrobial chemotherapy. 2013/04/13, 68(7). [Source]
Fraczek, M. G., Kirwan, M. B., Moore, C. B., Morris, J., Denning, D. W. and Richardson, M. D. (2014) ‘Volume dependency for culture of fungi from respiratory secretions and increased sensitivity of Aspergillus quantitative PCR.’ Mycoses. 2013/06/22, 57(2). [Source]
Hayes, G. E. and Denning, D. W. (2013) ‘Frequency, diagnosis and management of fungal respiratory infections.’ Current opinion in pulmonary medicine. 2013/02/16, 19(3). [Source]
Haylett, A. K., Felton, S., Denning, D. W. and Rhodes, L. E. (2013) ‘Voriconazole-induced photosensitivity: photobiological assessment of a case series of 12 patients.’ The British journal of dermatology. 2012/08/07, 168(1). [Source]
Howard, S. J., Pasqualotto, A. C., Anderson, M. J., Leatherbarrow, H., Albarrag, A. M., Harrison, E., Gregson, L., Bowyer, P. and Denning, D. W. (2013) ‘Major variations in Aspergillus fumigatus arising within aspergillomas in chronic pulmonary aspergillosis.’ Mycoses. 2013/02/02, 56(4). [Source]

2012

Aquino, V. R., Nagel, F., Andreolla, H. F., de-Paris, F., Xavier, M. O., Goldani, L. Z., Denning, D. W. and Pasqualotto, A. C. (2012) ‘The performance of real-time PCR, galactomannan, and fungal culture in the diagnosis of invasive aspergillosis in ventilated patients with chronic obstructive pulmonary disease (COPD).’ Mycopathologia. 2012/03/03, 174(2). [Source]
Bowyer, P., Mosquera, J., Anderson, M., Birch, M., Bromley, M. and Denning, D. W. (2012) ‘Identification of novel genes conferring altered azole susceptibility in Aspergillus fumigatus.’ FEMS microbiology letters. 2012/04/19, 332(1). [PubMed]
Brown, G. D., Denning, D. W., Gow, N. A., Levitz, S. M., Netea, M. G. and White, T. C. (2012) ‘Hidden killers: human fungal infections.’ Science translational medicine. 2012/12/21, 4(165). [Source]
Brown, G. D., Denning, D. W. and Levitz, S. M. (2012) ‘Tackling human fungal infections.’ Science. 2012/05/15, 336(6082). [Source]
Buied, A., Moore, C. B., Denning, D. W. and Bowyer, P. (2013) ‘High-level expression of cyp51B in azole-resistant clinical Aspergillus fumigatus isolates.’ The Journal of antimicrobial chemotherapy. 2012/12/05, 68(3). [Source]
Chishimba, L., Niven, R. M., Cooley, J. and Denning, D. W. (2012) ‘Voriconazole and posaconazole improve asthma severity in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization.’ The Journal of asthma : official journal of the Association for the Care of Asthma. 2012/03/03, 49(4). [Source]
Chrdle, A., Mustakim, S., Bright-Thomas, R. J., Baxter, C. G., Felton, T. and Denning, D. W. (2012) ‘Aspergillus bronchitis without significant immunocompromise.’ Annals of the New York Academy of Sciences. 2012/12/13, 1272. [Source]
Denning, D. W., Pleuvry, A. and Cole, D. C. (2013a) ‘Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults.’ Medical mycology. 2012/12/06, 51(4). [Source]
Denning, D. W., Pleuvry, A. and Cole, D. C. (2013b) ‘Global burden of chronic pulmonary aspergillosis complicating sarcoidosis.’ The European respiratory journal. 2012/06/30, 41(3). [Source]
Gould, F. K., Denning, D. W., Elliott, T. S., Foweraker, J., Perry, J. D., Prendergast, B. D., Sandoe, J. A., Spry, M. J., Watkin, R. W. and Working Party of the British Society for Antimicrobial, C. (2012) ‘Guidelines for the diagnosis and antibiotic treatment of endocarditis in adults: a report of the Working Party of the British Society for Antimicrobial Chemotherapy.’ The Journal of antimicrobial chemotherapy. 2011/11/17, 67(2). [Source]
Harrison, E., Singh, A., Morris, J., Smith, N. L., Fraczek, M. G., Moore, C. B. and Denning, D. W. (2012) ‘Mannose-binding lectin genotype and serum levels in patients with chronic and allergic pulmonary aspergillosis.’ International journal of immunogenetics. 2012/01/10, 39(3). [PubMed]
Haylett, A. K., Felton, S., Denning, D. W. and Rhodes, L. E. (2013) ‘Voriconazole-induced photosensitivity: photobiological assessment of a case series of 12 patients.’ The British journal of dermatology. 2012/08/07, 168(1). [Source]
Joardar, V., Abrams, N. F., Hostetler, J., Paukstelis, P. J., Pakala, S., Pakala, S. B., Zafar, N., Abolude, O. O., Payne, G., Andrianopoulos, A., Denning, D. W. and Nierman, W. C. (2012) ‘Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.’ BMC genomics. 2012/12/14, 13. [PubMed]
Knutsen, A. P., Bush, R. K., Demain, J. G., Denning, D. W., Dixit, A., Fairs, A., Greenberger, P. A., Kariuki, B., Kita, H., Kurup, V. P., Moss, R. B., Niven, R. M., Pashley, C. H., Slavin, R. G., Vijay, H. M. and Wardlaw, A. J. (2012) ‘Fungi and allergic lower respiratory tract diseases.’ The Journal of allergy and clinical immunology. 2012/01/31, 129(2). [Source]
Pendleton, M. and Denning, D. W. (2012) ‘Multifocal pulmonary aspergillomas: case series and review.’ Annals of the New York Academy of Sciences. 2012/12/13, 1272. [Source]
Singh, B. and Denning, D. W. (2012) ‘Allergic bronchopulmonary mycosis due to Alternaria: Case report and review.’ Medical mycology case reports. 2012/01/01, 1(1). [PubMed]

2011

Adamama-Moraitou, K. K., Pardali, D., Day, M. J., Denning, D. W., Papazoglou, L., Papastefanou, A. and Rallis, T. S. (2011) ‘Aspergillus fumigatus Bronchopneumonia in a Hellenic Shepherd Dog.’ Journal of the American Animal Hospital Association. 2011/03/02, 47(2). [Source]
Albarrag, A. M., Anderson, M. J., Howard, S. J., Robson, G. D., Warn, P. A., Sanglard, D. and Denning, D. W. (2011) ‘Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter.’ Antimicrobial agents and chemotherapy. 2011/08/31, 55(11). [PubMed]
Baxter, C. G., Bishop, P., Low, S. E., Baiden-Amissah, K. and Denning, D. W. (2011) ‘Pulmonary aspergillosis: an alternative diagnosis to lung cancer after positive [18F]FDG positron emission tomography.’ Thorax. 2011/04/05, 66(7). [Source]
Baxter, C. G., Jones, A. M., Webb, K. and Denning, D. W. (2011) ‘Homogenisation of cystic fibrosis sputum by sonication–an essential step for Aspergillus PCR.’ Journal of microbiological methods. 2011/02/01, 85(1). [Source]
Baxter, C. G., Marshall, A., Roberts, M., Felton, T. W. and Denning, D. W. (2011) ‘Peripheral neuropathy in patients on long-term triazole antifungal therapy.’ The Journal of antimicrobial chemotherapy. 2011/06/21, 66(9). [Source]
Bowyer, P., Moore, C. B., Rautemaa, R., Denning, D. W. and Richardson, M. D. (2011) ‘Azole antifungal resistance today: focus on Aspergillus.’ Current infectious disease reports. 2011/09/21, 13(6). [Source]
Denning, D. W., Park, S., Lass-Florl, C., Fraczek, M. G., Kirwan, M., Gore, R., Smith, J., Bueid, A., Moore, C. B., Bowyer, P. and Perlin, D. S. (2011) ‘High-frequency triazole resistance found In nonculturable Aspergillus fumigatus from lungs of patients with chronic fungal disease.’ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2011/04/07, 52(9). [PubMed]
Denning, D. W. and Perlin, D. S. (2011) ‘Azole resistance in Aspergillus: a growing public health menace.’ Future microbiology. 2011/11/16, 6(11). [Source]
Denning, D. W., Pleuvry, A. and Cole, D. C. (2011) ‘Global burden of chronic pulmonary aspergillosis as a sequel to pulmonary tuberculosis.’ Bulletin of the World Health Organization. 2012/01/25, 89(12). [PubMed]
Gargani, Y., Bishop, P. and Denning, D. W. (2011) ‘Too many mouldy joints – marijuana and chronic pulmonary aspergillosis.’ Mediterranean journal of hematology and infectious diseases. 2011/06/01, 3(1). [PubMed]
Gould, F. K., Denning, D. W., Elliott, T. S., Foweraker, J., Perry, J. D., Prendergast, B. D., Sandoe, J. A., Spry, M. J., Watkin, R. W. and Working Party of the British Society for Antimicrobial, C. (2012) ‘Guidelines for the diagnosis and antibiotic treatment of endocarditis in adults: a report of the Working Party of the British Society for Antimicrobial Chemotherapy.’ The Journal of antimicrobial chemotherapy. 2011/11/17, 67(2). [Source]
Hauser, P. M., Bille, J., Lass-Florl, C., Geltner, C., Feldmesser, M., Levi, M., Patel, H., Muggia, V., Alexander, B., Hughes, M., Follett, S. A., Cui, X., Leung, F., Morgan, G., Moody, A., Perlin, D. S. and Denning, D. W. (2011) ‘Multicenter, prospective clinical evaluation of respiratory samples from subjects at risk for Pneumocystis jirovecii infection by use of a commercial real-time PCR assay.’ Journal of clinical microbiology. 2011/03/04, 49(5). [PubMed]
Hogan, C. and Denning, D. W. (2011) ‘Allergic bronchopulmonary aspergillosis and related allergic syndromes.’ Seminars in respiratory and critical care medicine. 2011/12/15, 32(6). [Source]
Howard, S. J., Harrison, E., Bowyer, P., Varga, J. and Denning, D. W. (2011) ‘Cryptic species and azole resistance in the Aspergillus niger complex.’ Antimicrobial agents and chemotherapy. 2011/07/20, 55(10). [PubMed]
Karadi, R. L., Gow, D., Kellett, M., Denning, D. W. and O’Driscoll, R. B. (2011) ‘Itraconazole associated quadriparesis and edema: a case report.’ Journal of medical case reports. 2011/04/12, 5. [PubMed]
Lass-Florl, C., Follett, S. A., Moody, A. and Denning, D. W. (2011) ‘Detection of Aspergillus in lung and other tissue samples using the MycAssay Aspergillus real-time PCR kit.’ Canadian journal of microbiology. 2011/08/25, 57(9). [Source]
Purcell, J., McKenna, J., Critten, P., Denning, D. W. and Hassan, I. A. (2011) ‘Mixed mould species in laboratory cultures of respiratory specimens: how should they be reported, and what are the indications for susceptibility testing?’ Journal of clinical pathology. 2011/01/11, 64(6). [Source]
Slater, J. L., Gregson, L., Denning, D. W. and Warn, P. A. (2011) ‘Pathogenicity of Aspergillus fumigatus mutants assessed in Galleria mellonella matches that in mice.’ Medical mycology. 2010/10/19, 49 Suppl 1. [Source]
Smith, N. L. and Denning, D. W. (2011) ‘Underlying conditions in chronic pulmonary aspergillosis including simple aspergilloma.’ The European respiratory journal. 2010/07/03, 37(4). [Source]
Tuckwell, D., Denning, D. W. and Bowyer, P. (2011) ‘A public resource for metabolic pathway mapping of Aspergillus fumigatus Af293.’ Medical mycology. 2010/05/29, 49 Suppl 1. [Source]

2010

Bueid, A., Howard, S. J., Moore, C. B., Richardson, M. D., Harrison, E., Bowyer, P. and Denning, D. W. (2010) ‘Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009.’ The Journal of antimicrobial chemotherapy. 2010/08/24, 65(10). [Source]
Carvalho, A., Cunha, C., Pasqualotto, A. C., Pitzurra, L., Denning, D. W. and Romani, L. (2010) ‘Genetic variability of innate immunity impacts human susceptibility to fungal diseases.’ International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2009/10/16, 14(6). [Source]
Chai, L. Y., Denning, D. W. and Warn, P. (2010) ‘Candida tropicalis in human disease.’ Critical reviews in microbiology. 2010/10/05, 36(4). [Source]
Dannaoui, E., Schwarz, P., Slany, M., Loeffler, J., Jorde, A. T., Cuenca-Estrella, M., Hauser, P. M., Shrief, R., Huerre, M., Freiberger, T., Gaustad, P., Rodriguez-Tudela, J. L., Bille, J., Denning, D. W., Bretagne, S. and Lortholary, O. (2010) ‘Molecular detection and identification of zygomycetes species from paraffin-embedded tissues in a murine model of disseminated zygomycosis: a collaborative European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection Study Group (EFISG) evaluation.’ Journal of clinical microbiology. 2010/04/09, 48(6). [PubMed]
Denning, D. W. and Hope, W. W. (2010) ‘Therapy for fungal diseases: opportunities and priorities.’ Trends in microbiology. 2010/03/09, 18(5). [Source]
Felton, T. W., Baxter, C., Moore, C. B., Roberts, S. A., Hope, W. W. and Denning, D. W. (2010) ‘Efficacy and safety of posaconazole for chronic pulmonary aspergillosis.’ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2010/11/09, 51(12). [Source]
Felton, T. W., Plested, V., Walsham, A., Dark, P., O’Driscoll, R. and Denning, D. W. (2010) ‘A 27-year-old woman with acute, severe asthma who developed respiratory failure.’ Chest. 2010/03/06, 137(3). [Source]
Fraczek, M. G., Rashid, R., Denson, M., Denning, D. W. and Bowyer, P. (2010) ‘Aspergillus fumigatus allergen expression is coordinately regulated in response to hydrogen peroxide and cyclic AMP.’ Clinical and molecular allergy : CMA. 2010/11/05, 8. [PubMed]
Harrison, E., Stalhberger, T., Whelan, R., Sugrue, M., Wingard, J. R., Alexander, B. D., Follett, S. A., Bowyer, P. and Denning, D. W. (2010) ‘Aspergillus DNA contamination in blood collection tubes.’ Diagnostic microbiology and infectious disease. 2010/07/20, 67(4). [PubMed]
Hedayati, M. T., Mayahi, S. and Denning, D. W. (2010) ‘A study on Aspergillus species in houses of asthmatic patients from Sari City, Iran and a brief review of the health effects of exposure to indoor Aspergillus.’ Environmental monitoring and assessment. 2009/08/22, 168(1–4). [Source]
Hiemenz, J. W., Raad, I., Maertens, J. A., Hachem, R. Y., Saah, A. J., Sable, C. A., Chodakewitz, J. A., Severino, M. E., Saddier, P., Berman, R. S., Ryan, D. M., Dinubile, M. J., Patterson, T. F., Denning, D. W. and Walsh, T. J. (2010) ‘Efficacy of caspofungin as salvage therapy for invasive aspergillosis compared to standard therapy in a historical cohort.’ European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2010/08/13, 29(11). [Source]
Howard, S. J., Pasqualotto, A. C. and Denning, D. W. (2010) ‘Azole resistance in allergic bronchopulmonary aspergillosis and Aspergillus bronchitis.’ Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2009/08/14, 16(6). [Source]
Lestner, J. M. and Denning, D. W. (2010) ‘Tremor: a newly described adverse event with long-term itraconazole therapy.’ Journal of neurology, neurosurgery, and psychiatry. 2010/02/27, 81(3). [Source]
Slater, J. L., Gregson, L., Denning, D. W. and Warn, P. A. (2011) ‘Pathogenicity of Aspergillus fumigatus mutants assessed in Galleria mellonella matches that in mice.’ Medical mycology. 2010/10/19, 49 Suppl 1. [Source]
Smith, N. L. and Denning, D. W. (2011) ‘Underlying conditions in chronic pulmonary aspergillosis including simple aspergilloma.’ The European respiratory journal. 2010/07/03, 37(4). [Source]
Tuckwell, D., Denning, D. W. and Bowyer, P. (2011) ‘A public resource for metabolic pathway mapping of Aspergillus fumigatus Af293.’ Medical mycology. 2010/05/29, 49 Suppl 1. [Source]
Warn, P. A., Sharp, A., Morrissey, G. and Denning, D. W. (2010) ‘Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus.’ International journal of antimicrobial agents. 2009/12/18, 35(2). [Source]